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Original Article

Decreased Endothelial Progenitor Cells in Umbilical Cord Blood in Severe Preeclampsia

Kwon J.-Y.a · Maeng Y.-S.b · Kwon Y.-G.b · Kim Y.-H.a · Kang M.-H.c · Park Y.-W.a, c

Author affiliations

aDepartment of Obstetrics and Gynecology, Yonsei University College of Medicine, bDepartment of Biochemistry, Yonsei University, and cWomen’s Life Science Institute, Yonsei University College of Medicine, Seoul, Korea

Related Articles for ""

Gynecol Obstet Invest 2007;64:103–108

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: November 07, 2005
Accepted: September 18, 2006
Published online: February 23, 2007
Issue release date: August 2007

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI

Abstract

Background/Aims: We compared the numbers of endothelial progenitor cells (EPCs) in umbilical cord blood in severe preeclampsia and normal pregnancy, along with the cord blood plasma levels of free VEGF and sVEGFR-1. Methods: Umbilical cord blood EPC counts in severe preeclampsia (n = 15) and gestationally matched normal pregnant women (n = 30) were retrospectively analyzed. Cord plasma free VEGF and sVEGFR-1 levels were measured by enzyme immunoassay. Results: Significantly higher systolic blood pressure, lower birth weight, and higher rate of small for gestational age were noted in the severe preeclampsia group. Circulating EPCs in cord blood and umbilical cord plasma free VEGF were significantly decreased in severe preeclampsia compared to the control group (p = 0.009 and 0.04, respectively). Conclusion: In severe preeclampsia, cord blood EPCs were reduced markedly and this was accompanied by a significant decrease in cord plasma free VEGF which is known to play a role in EPC mobilization.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: November 07, 2005
Accepted: September 18, 2006
Published online: February 23, 2007
Issue release date: August 2007

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


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