The Fetal Dandy Walker Complex: Associated Anomalies, Perinatal Outcome and Postnatal ImagingHarper T. · Fordham L.A. · Wolfe H.M.
Departments of aObstetrics and Gynecology and bRadiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C., USA
Objective: This study compares the diagnostic accuracy of prenatal ultrasound with postnatal imaging and evaluates for associated fetal anomalies and their impact on immediate neonatal outcome in fetal Dandy Walker complex (DWC). Methods: Cases of fetal DWC diagnosed in a single ultrasound unit from January 2000 through July 2004 were reviewed for associated fetal anomalies, fetal karyotype, immediate neonatal outcome and postnatal head imaging. Results: A total of 55 fetuses with DWC were identified. Of liveborn cases, postnatal imaging confirmed prenatal intracranial findings in 50% of Dandy Walker variant (DWV) and 100% of Dandy Walker malformation (DWM), with additional central nervous system findings noted in 21% of all cases. Additional fetal anomalies were seen in 26/40 (65%) cases of DWV and 15/15 (100%) cases of DWM. Immediate neonatal survival was predicted by karyotype and associated fetal anomalies. Conclusion: The sonographic diagnosis of fetal DWM is accurate. Significant discrepancies exist in prenatal and postnatal diagnosis of DWV. Comprehensive fetal ultrasound and karyotype should be offered for all fetuses with DWC. Postnatal imaging should be performed on all fetal DWC.
Honor Wolfe, MD
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology
University of North Carolina at Chapel Hill
214 MacNider, CB 7516, 101 Manning Dr., Chapel Hill NC 27599 (USA)
Tel. +1 919 966 1601, Fax +1 919 966 6377, E-Mail firstname.lastname@example.org
Number of Print Pages : 5
Number of Figures : 1, Number of Tables : 4, Number of References : 16
Fetal Diagnosis and Therapy (Clinical Advances and Basic Research)
Vol. 22, No. 4, Year 2007 (Cover Date: June 2007)
Journal Editor: Holzgreve, W. (Basel)
ISSN: 1015–3837 (print), 1421–9964 (Online)
For additional information: http://www.karger.com/FDT