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Vol. 92, No. 2, 2007
Issue release date: August 2007
Section title: Original Paper
Neonatology 2007;92:96–104
(DOI:10.1159/000100808)

Antiviral Activity of Purified Human Breast Milk Mucin

Habte H.H. · Kotwal G.J. · Lotz Z.E. · Tyler M.G. · Abrahams M. · Rodriques J. · Kahn D. · Mall A.S.
Departments of aSurgery, bMedical Virology and cMolecular and Cell Biology, University of Cape Town, Cape Town, South Africa

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 6/3/2006
Accepted: 12/6/2006
Published online: 3/14/2007

Number of Print Pages: 9
Number of Figures: 9
Number of Tables: 1

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO

Abstract

Human breast milk is known to contain numerous biologically active components which protect breast fed infants against microbes, viruses, and toxins. The purpose of this study was to purify and characterize the breast milk mucin and determine its anti-poxvirus activity. In this study human milk mucin, free of contaminant protein and of sufficient quantity for further analysis, was isolated and purified by Sepharose CL-4B gel filtration and cesiumchloride density-gradient centrifugation. Based on the criteria of size and appearance of the bands and their electrophoretic mobility on sodium dodecyl sulfate polyacrylamide-gel electrophoresis, Western blotting together with the amino acid analysis, it is very likely that the human breast milk mucin is MUC1. It was shown that this breast milk mucin inhibits poxvirus activity by 100% using an inhibition assay with a viral concentration of 2.4 million plaque-forming units/ml. As the milk mucin seems to aggregate poxviruses prior to their entry into host cells, it is possible that this mucin may also inhibit other enveloped viruses such as HIV from entry into host cells.


  

Author Contacts

Anwar S. Mall, PhD
Department of Surgery, University of Cape Town
J-Floor, Old Main Building, Groote Schuur Hospital, Observatory 7925
Cape Town (South Africa)
Tel. +27 21 406 6168, Fax +27 21 448 6461, E-Mail amall@uctgsh1.uct.ac.za

  

Article Information

Received: June 3, 2006
Accepted after revision: December 6, 2006
Published online: March 14, 2007
Number of Print Pages : 9
Number of Figures : 9, Number of Tables : 1, Number of References : 28

  

Publication Details

Neonatology (Fetal and Neonatal Research)

Vol. 92, No. 2, Year 2007 (Cover Date: August 2007)

Journal Editor: Halliday, H.L. (Belfast)
ISSN: 1661–7800 (print), 1661–7819 (Online)

For additional information: http://www.karger.com/NEO


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 6/3/2006
Accepted: 12/6/2006
Published online: 3/14/2007

Number of Print Pages: 9
Number of Figures: 9
Number of Tables: 1

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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