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Table of Contents
Vol. 51, No. 1, 2007
Issue release date: April 2007
Section title: Original Paper
Ann Nutr Metab 2007;51:35–41
(DOI:10.1159/000100819)

Ultrasonographic Measurement of Intra-Abdominal Fat Thickness in HIV-Infected Patients Treated or Not with Antiretroviral Drugs and Its Correlation to Lipid and Glycemic Profiles

Guimarães M.M.M. · de Oliveira Júnior A.R. · Penido M.G. · Queiroz L.C. · Goulart E.M.A. · Greco D.B. · Machado L.J.C.
Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 13, 2006
Accepted: August 08, 2006
Published online: March 14, 2007
Issue release date: April 2007

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM

Abstract

Aims: To compare the intra-abdominal fat thickness measured by ultrasound between HIV-infected patients treated or not with antiretroviral drugs and to correlate these visceral adiposity measurements to other parameters of cardiovascular risks. Methods: In a transversal observational study, 160 HIV-infected patients were recruited and divided in two groups, i.e., 123 antiretroviral (ARV)-treated and 37 ARV-naïve patients. These patients were submitted to anthropometric determinations, laboratorial analysis, ultrasonographic measurements of subcutaneous and intra- abdominal fat thickness and to tetrapolar bioelectrical impedance analysis in order to measure the body composition. Results: In the patients treated with highly active antiretroviral therapy (HAART) the intra-abdominal fat pad was significantly thicker than that of the untreated group (69 ± 21 mm, n = 123 vs. 60 ± 18 mm, n = 37; p = 0.03 Student’s t test). The intra-abdominal fat thickness correlated significantly with plasma triglyceride, total cholesterol, fasting glucose, glucose measurements 2 h after dextrose load, fasting insulin, HOMA-IR index, systolic and diastolic blood pressures, weight, BMI, WHR and caliper-measured total fat percentage. Conclusion: The results showed that antiretroviral therapy is associated with increased ultrasonographic measurements of visceral adiposity. Our data demonstrated a strong correlation between intra-abdominal fat thickness and independent risk factors of cardiovascular disease: atherogenic lipid profile and insulin resistance.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 13, 2006
Accepted: August 08, 2006
Published online: March 14, 2007
Issue release date: April 2007

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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