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Cover

Superantigens and Superallergens

Editor(s): Marone G. (Naples) 
Table of Contents
Vol. 93, No. , 2007
Section title: Paper
Marone G (ed): Superantigens and Superallergens. Chem Immunol Allergy. Basel, Karger, 2007, vol 93, pp 106-136
(DOI:10.1159/000100861)

The Allergic March from Staphylococcus aureus Superantigens to Immunoglobulin E

Gould H.a · Takhar P.a · Harries H.a · Chevretton E.b · Sutton B.a
aDivisions of Cell and Molecular Biophysics and Allergy, Asthma and Lung Biology, and MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King’s College London, and b Department of ENT Surgery, Guy’s and St. Thomas’ NHS Trust, London, UK

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: March 12, 2007
Cover Date: 2007

Number of Print Pages: 31
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8266-7 (Print)
eISBN: 978-3-318-01451-8 (Online)

Abstract

Staphylococcus aureus is a commensal bacterium in the respiratory tract mucosa of most people and infects the skin of atopic dermatitis patients. This might imply a symbiotic relationship between host and bacterium or a standoff between bacterial infection and the host immune system. But superantigens produced by S. aureus in these locations are of particular interest because they are strongly implicated in the pathogenesis of allergic disorders and airway disease. They appear to act locally in these conditions by stimulating polyclonal T cell and B cell proliferation and driving somatic hypermutation, class switching to immunoglobulin (Ig) E and the production of allergen-specific IgE in mucosal B cells. IgE antibodies directed against the superantigens (‘superallergens’) themselves engender chronic inflammation and the persistent sensitization to conventional allergens of mast cells and antigen-presenting cells in mucosal tissues in atopic dermatitis, rhinitis and asthma. Moreover, S. aureus superantigens inhibit the activity of T regulatory cells that normally control inflammation, and generate a state of steroid resistance that confounds treatment of allergic disorders and airway disease.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: March 12, 2007
Cover Date: 2007

Number of Print Pages: 31
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8266-7 (Print)
eISBN: 978-3-318-01451-8 (Online)


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.