Cover

Superantigens and Superallergens

Editor(s): Marone G. (Naples) 
Table of Contents
Vol. 93, No. , 2007
Section title: Paper
Marone G (ed): Superantigens and Superallergens. Chem Immunol Allergy. Basel, Karger, 2007, vol 93, pp 161-180
(DOI:10.1159/000100894)

T Cell Signalling Induced by Bacterial Superantigens

Bueno C.a-c · Criado G.a-c · McCormick J.c,d · Madrenas J.a-c,e
aFOCIS Centre for Clinical Immunology and Immunotherapeutics, b Robarts Research Institute, Departments of c Microbiology and Immunology, and e Medicine, University of Western Ontario, and d Lawson Health Research Institute, London, Ont., Canada

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 3/12/2007
Cover Date: 2007

Number of Print Pages: 20
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8266-7 (Print)
eISBN: 978-3-318-01451-8 (Online)

Abstract

Bacterial superantigens (SAgs) constitute a large family of bacterial toxins that share the capacity to induce massive activation of the human immune system. Such a feature is based on the ability of these toxins to activate T cells that express Β-chains of the T cell antigen receptor (TCR) containing variable regions (V) coded by specific families of VΒ genes. In addition, bacterial SAgs bypass the need for processing by antigen-presenting cells by directly binding to major histocompatibility complex class II molecules on the surface of these cells. Emerging work indicates that bacterial SAgs utilize not only the canonical pathways of TCR-mediated T cell activation but also other pathways. Here, we review the structural information on recognition of bacterial SAgs by T cells, the TCR signalling induced by this recognition event, and the effector functions that this recognition triggers. We analyze experimental evidence suggesting the existence of alternative receptors and coreceptors for bacterial SAgs, and outline future challenges in the research with these toxins.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 3/12/2007
Cover Date: 2007

Number of Print Pages: 20
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8266-7 (Print)
eISBN: 978-3-318-01451-8 (Online)


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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