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Table of Contents
Vol. 30, No. 2, 2007
Issue release date: April 2007
Section title: Review
Kidney Blood Press Res 2007;30:97–107
(DOI:10.1159/000100905)

Causes and Consequences of Increased Arterial Stiffness in Chronic Kidney Disease Patients

Gusbeth-Tatomir P. · Covic A.
Dialysis and Renal Transplantation Center, Parhon University Hospital, Iasi, Romania

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: October 11, 2006
Accepted: February 02, 2007
Published online: March 19, 2007
Issue release date: April 2007

Number of Print Pages: 11
Number of Figures: 1
Number of Tables: 0

ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)

For additional information: http://www.karger.com/KBR

Abstract

Cardiovascular (CV) morbidity and mortality is greatly enhanced in patients with chronic kidney disease, compared to the non-renal population. One key element of this high CV burden appears to be arterial stiffness, as an expression of premature vascular aging. Increased arterial stiffness in renal patients may be a consequence of vascular calcification, chronic volume overload, inflammation, endothelial dysfunction, oxidative stress and several other factors. The authors review briefly the main pathophysiological mechanisms leading to reduced arterial compliance. Increased arterial stiffness has significant clinical consequences: isolated systolic hypertension, left ventricular hypertrophy (and failure), and reduced myocardial perfusion. Better knowledge of the mechanisms of arterial functional and morphologic alteration may help in developing more refined therapeutic strategies aimed to reduce the high CV burden in chronic kidney disease. The potential therapeutic interventions – mainly the use of certain antihypertensive drugs and reduction of vascular calcification – are finally discussed.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Review

Received: October 11, 2006
Accepted: February 02, 2007
Published online: March 19, 2007
Issue release date: April 2007

Number of Print Pages: 11
Number of Figures: 1
Number of Tables: 0

ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)

For additional information: http://www.karger.com/KBR


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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