Prediction of Alzheimer’s Disease Using the CSF Aβ42/Aβ40 Ratio in Patients with Mild Cognitive ImpairmentHansson O. · Zetterberg H. · Buchhave P. · Andreasson U. · Londos E. · Minthon L. · Blennow K.
aClinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, and bNeuropsychiatric Clinic, Malmö University Hospital, Malmö, cInstitute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, and dInstitute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Göteborg University, Göteborg, Sweden
Evidence supports an important role for β-amyloid (Aβ) in the pathogenesis of Alzheimer’s disease (AD). Here, we investigate baseline levels of the 40- and 42-amino-acid-long Aβ peptides (Aβ40 and Aβ42) in cerebrospinal fluid (CSF) from a cohort of patients with mild cognitive impairment (MCI, n = 137) in relation to the final diagnosis after 4–6 years of follow-up time. CSF Aβ42 concentration at baseline and the Aβ42/Aβ40 ratio were significantly decreased in the MCI patients who developed AD as compared to cognitively stable MCI patients and MCI patients who developed other forms of dementia (p < 0.001). The baseline levels of Aβ40 were similar in all MCI groups but correlated with change in Mini Mental State Examination scores in converters to AD. The Aβ42/Aβ40 ratio was superior to Aβ42 concentration with regard to identifying incipient AD in MCI (p < 0.05). In conclusion, the data provide further support for the view that amyloid precursor protein metabolism is disturbed in early sporadic AD and points to the usefulness of the Aβ42/Aβ40 ratio as a predictive biomarker for AD.
Henrik Zetterberg, MD, PhD
Department of Neurochemistry and Psychiatry
Institute of Neuroscience and Physiology, Sahlgrenska University Hospital/Mölndal
SE–431 80 Mölndal (Sweden)
Tel. +46 31 343 23 77, Fax +46 31 343 24 26, E-Mail email@example.com
O.H. and H.Z. contributed equally to this work.
Accepted: January 18, 2007
Published online: March 19, 2007
Number of Print Pages : 5
Number of Figures : 2, Number of Tables : 1, Number of References : 24
Dementia and Geriatric Cognitive Disorders
Vol. 23, No. 5, Year 2007 (Cover Date: April 2007)
Journal Editor: Chan-Palay, V. (New York, N.Y.)
ISSN: 1420–8008 (print), 1421–9824 (Online)
For additional information: http://www.karger.com/DEM