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Vol. 51, No. 1, 2007
Issue release date: April 2007
Section title: Original Paper
Ann Nutr Metab 2007;51:88–95
(DOI:10.1159/000100954)

Interleukin-6, C-Reactive Protein and Biochemical Parameters during Prolonged Intermittent Fasting

Aksungar F.B. · Topkaya A.E. · Akyildiz M.
Departments of aBiochemistry, bMicrobiology and cCardiovascular Surgery, Maltepe University, School of Medicine, Istanbul, Turkey

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/26/2006
Accepted: 12/27/2006
Published online: 3/19/2007

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 2

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM

Abstract

Background: It is well known that nutritional habits, sleeping patterns and meal frequency have profound effects on maintaining human health. Ramadan is a religious month for Islam, during which Muslims do not eat and drink during the daylight hours. The duration of restricted food and beverage intake is approximately 12 h/day for 1 month, which makes Ramadan a model of prolonged intermittent fasting. Methods: In order to evaluate the effects of long-lasting modifications of food intake on inflammatory markers and biochemical parameters 40 healthy volunteers of normal weight [20 females aged between 20 and 38 years, 20 males aged between 23 and 39 years, body mass index (BMI) <25 kg/m2] who fasted during Ramadan and another 28 healthy age- and BMI-matched volunteers (14 males, 14 females) who did not fast participated in the study. Venous blood samples were taken 1 week before Ramadan, during the last week of Ramadan and 3 weeks after Ramadan. Serum interleukin-6 (IL-6), C-reactive protein (CRP), homocysteine, vitamin B12, folate, total cholesterol (TC), triglycerides, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) levels were measured. Results: No significant changes were observed in serum total cholesterol, triglycerides and LDL levels. TC/HDL ratio (HDL risk factor) was decreased during and after Ramadan in both genders in the fasting group while there were no changes in the nonfasting group. IL-6 (p < 0.001), CRP (p < 0.001) and homocysteine (p < 0.01) levels were significantly low during Ramadan in the fasting subjects of both genders when compared to basal values (1 week before Ramadan). Conclusion: Our results demonstrate that prolonged intermittent fasting in a model like Ramadan has some positive effects on the inflammatory status of the body and on the risk factors for cardiovascular diseases such as homocysteine, CRP and TC/HDL ratio.


  

Author Contacts

Dr. Fehime Benli Aksungar
Department of Biochemistry, Maltepe University, School of Medicine
Atatürk Caddesi, Çam Sok, No 3/A, Maltepe
TR–34844 İstanbul (Turkey)
Tel. +90 216 399 9750, Fax +90 216 457 5979, E-Mail fehimebenli@gmail.com

  

Article Information

Received: May 26, 2006
Accepted: December 27, 2006
Published online: March 19, 2007
Number of Print Pages : 8
Number of Figures : 3, Number of Tables : 2, Number of References : 29

  

Publication Details

Annals of Nutrition and Metabolism (European Journal of Nutrition, Metabolic Diseases and Dietetics)

Vol. 51, No. 1, Year 2007 (Cover Date: April 2007)

Journal Editor: Elmadfa, I. (Vienna)
ISSN: 0250–6807 (print), 1421–9697 (Online)

For additional information: http://www.karger.com/ANM


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/26/2006
Accepted: 12/27/2006
Published online: 3/19/2007

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 2

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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