Components of the diet related to changes in eating habits that characterize the modern
Western world are important factors in the increasingly high prevalence of chronic disease,
including obesity, diabetes, hypertension and as a consequence, chronic kidney disease. The
healthy diets recommended for the general population to promote longevity (such as the
Mediterranean diet), are defined based on epidemiological and intervention studies and are
usually characterized by a relatively higher amount of protein than the usual Western diet.
Unfortunately, very few clinical studies focused on diet-based strategies of prevention of kidney
disorders. Furthermore, this review will propose that the concept that protein restricted
diets decrease the risk of developing kidney disease in the general population is not supported
by the scientific literature. Indeed, preliminary studies showing a positive effect of
relatively high protein diets on risk factors for chronic kidney disease (particularly on obesity,
hypertension and diabetes) point to the need for future studies addressing diets that
could prevent the increasingly high prevalence of kidney disease in the Western world. On
the other hand, there is a potential role for protein restriction in patients with established kidney
disease, particularly in patients with significant decrease in glomerular filtration rate.
The exact protective action of protein restriction in patients with established renal disease
needs further analysis, taking into account the more broad effects of protein restriction (lower
phosphate, acidosis, uric acid) and a more current definition of malnutrition.
Copyright / Drug Dosage
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