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Bispecific Antibodies: Molecules That Enable Novel Therapeutic Strategies

Fischer N. · Léger O.

Author affiliations

NovImmune SA, Geneva, Switzerland

Corresponding Author

N. Fischer

NovImmune SA

64 av. De la Roseraie

CH–1211 Geneva 4 (Switzerland)

Tel. +41 22 593 5110, Fax +41 22 593 5109, E-Mail nfischer@novimmune.com

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Pathobiology 2007;74:3–14

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Bispecific antibodies are unique in the sense that they can bind simultaneously two different antigens. This property enables the development of therapeutic strategies that are not possible with conventional monoclonal antibodies. The large panel of imaginative bispecific antibody formats that has been developed reflects the strong interest for these molecules. Although in many cases the manufacturing of clinical grade material remains challenging, several bispecific antibody formats are currently in clinical trials.

© 2007 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Review

Received: October 24, 2006
Accepted: February 01, 2007
Published online: May 21, 2007
Issue release date: May 2007

Number of Print Pages: 12
Number of Figures: 2
Number of Tables: 1

ISSN: 1015-2008 (Print)
eISSN: 1423-0291 (Online)

For additional information: http://www.karger.com/PAT

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