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Vol. 74, No. 4, 2007
Issue release date: July 2007
Section title: Basic Science Investigations
Respiration 2007;74:454–459
(DOI:10.1159/000101057)

Interleukin-10 Regulates Transforming Growth Factor-β Signaling in Cultured Human Bronchial Epithelial Cells

Fueki N.a, b · Sagara H.a · Akimoto K.c · Ota M.a · Okada T.a · Sugiyama K.a · Fueki M.a, b · Makino S.b · Fukuda T.a
aDepartment of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Mibu, Tochigi, bJobu Hospital for Respiratory Medicine, Maebashi, Gunma, and cInstitute for Medical Science, Dokkyo Medical University, Mibu, Tochigi, Japan

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Article / Publication Details

First-Page Preview
Abstract of Basic Science Investigations

Published online: 3/23/2007
Issue release date: July 2007

Number of Print Pages: 6
Number of Figures: 6
Number of Tables: 0

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES

Abstract

Background: The basic pathological features of bronchial asthma can be explained on the basis of chronic airway inflammation, involving inflammatory cells such as T cells (particularly type 2 helper T, Th2, cells) and mast cells, and airway remodeling. Many aspects of airway remodeling remain unclear at the molecular level. Recent attention has focused on the role of transforming growth factor (TGF)-β, a fibrogenic cytokine, in airway remodeling. Currently available evidence suggests that airway remodeling is caused by an imbalance in regulatory mechanisms mediated by Smads, a family of signal-transducing molecules. Objectives: We studied the effects of the Th2 cytokines interleukin (IL)-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF), and the regulatory cytokine IL-10 on the expression of inhibitory Smad7 protein in bronchial epithelial cells. Methods: Real-time reverse-transcriptase polymerase chain reaction was employed. Results: Stimulation with IL-10 upregulated the expression of Smad7 compared with control. Neither IL-5 nor GM-CSF induced Smad7 expression. Smad7 expression was upregulated by IL-10 plus either IL-5 or GM-CSF. IL-10 inhibited the expression of TGF-β-inducible early gene, which is known to downregulate Smad7 expression. Conclusions: Our results suggest that IL-10 acts as a regulatory cytokine in the inhibition of airway inflammation.

© 2007 S. Karger AG, Basel


  

Author Contacts

Dr. Hironori Sagara
Department of Pulmonary Medicine and Clinical Immunology
Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu
Tochigi 321-0293 (Japan)
Tel. +81 282 86 1111, Fax +81 282 86 5080, E-Mail h-sagara@dokkyomed.ac.jp

  

Article Information

Dr. Fueki and Dr. Sagara contributed equally to this work.

Received: August 30, 2006
Accepted after revision: December 19, 2006
Published online: March 23, 2007
Number of Print Pages : 6
Number of Figures : 6, Number of Tables : 0, Number of References : 29

  

Publication Details

Respiration (International Journal of Thoracic Medicine)

Vol. 74, No. 4, Year 2007 (Cover Date: July 2007)

Journal Editor: Bolliger, C.T. (Cape Town)
ISSN: 0025–7931 (print), 1423–0356 (Online)

For additional information: http://www.karger.com/RES


Article / Publication Details

First-Page Preview
Abstract of Basic Science Investigations

Published online: 3/23/2007
Issue release date: July 2007

Number of Print Pages: 6
Number of Figures: 6
Number of Tables: 0

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES


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