Transforming Growth Factor-β and microRNA:mRNA Regulatory Networks in Epithelial PlasticityZavadil J. · Narasimhan M. · Blumenberg M. · Schneider R.J.
aDepartment of Pathology and NYU Cancer Institute, and Departments of bMicrobiology and cDermatology, New York University School of Medicine, New York, N.Y., USA
Noncoding microRNAs act as posttranscriptional repressors of gene function and are often deregulated in cancers and other diseases. Here we review recent findings on microRNA roles in tumorigenesis and report a microRNA profiling screen in transforming growth factor-β1 (TGF-β)-induced epithelial-mesenchymal transition (EMT) in human keratinocytes, a model of epithelial cell plasticity underlying epidermal injury and skin carcinogenesis. We describe a novel EMT-specific microRNA signature that includes induction of miR-21, a candidate oncogenic microRNA associated with carcinogenesis. By integrating the microRNA screen results with target prediction algorithms and gene expression profiling data, we outline a framework for TGF-β-directed microRNA:messenger RNA (mRNA) regulatory circuitry and discuss its biological relevance for tumor progression.
Dr. Jiri Zavadil
New York University School of Medicine and NYU Cancer Institute
400 E 34th Street, RR809A
New York, NY 10016 (USA)
Tel. +1 212 263 8048, Fax +1 212 263 0443, E-Mail email@example.com
Number of Print Pages : 5
Number of Figures : 1, Number of Tables : 1, Number of References : 28
Cells Tissues Organs (in vivo, in vitro)
Vol. 185, No. 1-3, Year 2007 (Cover Date: June 2007)
Journal Editor: Denker, H.-W. (Essen)
ISSN: 1422–6405 (print), 1422–6421 (Online)
For additional information: http://www.karger.com/CTO