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Table of Contents
Vol. 185, No. 1-3, 2007
Issue release date: June 2007
Section title: Paper
Cells Tissues Organs 2007;185:162–174
(DOI:10.1159/000101317)

Chromatin Structure Regulation in Transforming Growth Factor-β-Directed Epithelial-Mesenchymal Transition

Blumenberg M.a · Gao S.b · Dickman K.b, c · Grollman A.P.b · Bottinger E.P.d · Zavadil J.e
aDepartment of Dermatology, New York University School of Medicine, bDepartment of Pharmacological Sciences, SUNY Stony Brook, cDepartment of Medicine, VA Medical Center, Northport, dDepartment of Medicine, Mount Sinai Medical Center, and eDepartment of Pathology and NYU Cancer Institute, New York University School of Medicine, New York, N.Y., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: May 09, 2006
Accepted: September 26, 2006
Published online: June 25, 2007
Issue release date: June 2007

Number of Print Pages: 13
Number of Figures: 3
Number of Tables: 1

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO

Abstract

Epithelial-mesenchymal transitions (EMTs) occur in organogenesis throughout embryonic development and are recapitulated during epithelial tissue injury and in carcinoma progression. EMTs are regulated by complex, precisely orchestrated cell signaling and gene expression networks, with the participation of key developmental pathways. Here we review context-dependent modules of gene regulation by hairy/enhancer-of-split-related (H/E(spl)) repressors downstream of transforming growth factor-β (TGF-β)/Smad and Notch signals in EMT and in other phenotype transitions such as differentiation and cancer. Based on multiple models of disease-related EMT, we propose that Polycomb group epigenetic silencers and histone-lysine methyl-transferases EZH1 and EZH2 are candidate targets of H/E(spl)-mediated transcriptional repression, in a process accompanied by replacement of modified core histone H3 with de novo synthesized histone variant H3.3B. Finally, we discuss the potential significance of this scenario for EMT in the light of recent findings on gene regulation by histone modifications and chromatin structure changes.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: May 09, 2006
Accepted: September 26, 2006
Published online: June 25, 2007
Issue release date: June 2007

Number of Print Pages: 13
Number of Figures: 3
Number of Tables: 1

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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