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Table of Contents
Vol. 68, No. 5, 2007
Issue release date: October 2007
Section title: Original Paper
Horm Res 2007;68:225–230
(DOI:10.1159/000101335)

The Relationship between Nocturnal Urinary Leptin and Gonadotrophins as Children Progress towards Puberty

Maqsood A.R.a · Trueman J.A.a · Whatmore A.J.a · Westwood M.a · Price D.A.b · Hall C.M.b · Clayton P.E.a, b
aEndocrine Sciences Research Group, Division of Human Development, School of Medicine, University of Manchester, Manchester, and bDepartment of Paediatric Endocrinology, Royal Manchester Children’s Hospital, Pendlebury, UK

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 03, 2006
Accepted: January 30, 2007
Published online: March 28, 2007
Issue release date: October 2007

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 3

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

Background/Aims: Leptin is necessary for normal human pubertal development but its exact role in the period leading up to the onset of puberty has not been defined. This study has assessed the relationship between leptin and gonadotrophin secretion over time as children progress into puberty. Subjects and Methods: Twenty children (13 boys and 7 girls) judged to be close to the initiation of puberty were recruited. Three consecutive first morning urine samples were collected from each subject each month over 6 months. At the end of the study, the children were classified into those who remained physically prepubertal (n = 7) and those that had advanced in puberty (n = 13). Leptin and gonadotrophins were measured by immunoradiometric and immunofluorometric assay, respectively. Results: Total urinary leptin excreted over 6 months was higher in girls than in boys, both prepubertally and in early puberty, and in both sexes, was higher in those advancing into puberty than in those remaining prepubertal (girls 8.0 vs. 3.4 ng/l and boys 3.6 vs. 1.7 ng/l; both p < 0.05). In the whole group, when controlling for gender, there was a significant correlation between both leptin and luteinizing hormone (LH; r = 0.43, p < 0.001) and leptin and follicle-stimulating hormone (FSH; r = 0.32, p = 0.001). The possibility of a lead relationship was explored by pairing leptin values with the gonadotrophin values in the following month. Leptin was significantly correlated with FSH but not LH in both pre- and peripubertal children (prepubertal r = 0.45, p = 0.01; peripubertal r = 0.32, p = 0.01). Conclusions: This study has shown that in children approaching and progressing into puberty, leptin is associated with LH and FSH over the same time frame, and with FSH when leptin is acting as the lead hormone. These data imply that leptin is an important facilitator of the early phases of human puberty.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 03, 2006
Accepted: January 30, 2007
Published online: March 28, 2007
Issue release date: October 2007

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 3

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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