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Table of Contents
Vol. 27, No. 3, 2007
Issue release date: May 2007
Section title: Original Report: Patient-Oriented, Translational Research
Am J Nephrol 2007;27:226–231
(DOI:10.1159/000101367)

Corticosteroids and Ciclosporin A in Idiopathic Membranous Nephropathy: Higher Remission Rates of Nephrotic Syndrome and Less Adverse Reactions than after Traditional Treatment with Cytotoxic Drugs

Goumenos D.S.a · Katopodis K.P.b · Passadakis P.c · Vardaki E.d · Liakopoulos V.e · Dafnis E.d · Stefanidis I.e · Vargemezis V.c · Vlachojannis J.G.a · Siamopoulos K.C.b
Departments of Internal Medicine/Nephrology, University Hospitals of aPatras, bIoannina, cAlexandroupolis, dHeraklion, and eLarissa, Greece

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Article / Publication Details

First-Page Preview
Abstract of Original Report: Patient-Oriented, Translational Research

Received: December 22, 2006
Accepted: February 26, 2007
Published online: March 27, 2007
Issue release date: May 2007

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 1

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN

Abstract

Background/Aim: Idiopathic membranous nephropathy, the most common cause of nephrotic syndrome in adults, has been traditionally treated with corticosteroids and cytotoxic drugs. Ciclosporin A (CsA) is used in resistant cases, but also as a first-line treatment, due to the serious side effects of cytotoxic drugs. In this study, the remission rates of nephrotic syndrome and the incidence of side effects of corticosteroids and low CsA doses are compared with those after treatment with cytotoxic drugs. Methods: Seventy-seven nephrotic patients with well-preserved renal function who were treated with methylprednisolone and CsA (n = 46) or cytotoxic drugs (n = 31) were studied. The effects of treatments were estimated on the basis of remission rates of nephrotic syndrome and preservation of the renal function. Results: Remission (complete or partial) of nephrotic syndrome was observed in 85% of the patients treated with CsA and in 55% of the patients treated with cytotoxic drugs (p < 0.01). Deterioration of the renal function, more common in patients with multiple relapses and interstitial fibrosis, was observed in 26 and 23% of the patients, respectively (p = NS). Serious side effects and discontinuation of treatment were more frequent in patients treated with cytotoxic drugs (10 vs. 4%). Conclusion: The combination of corticosteroids with CsA represents a better regimen for patients having idiopathic membranous nephropathy, since it is associated with higher remission rates of nephrotic syndrome and less severe side effects than corticosteroids and cytotoxic drugs.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Report: Patient-Oriented, Translational Research

Received: December 22, 2006
Accepted: February 26, 2007
Published online: March 27, 2007
Issue release date: May 2007

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 1

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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