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Vol. 20, No. 4, 2007
Issue release date: June 2007
Section title: Original Paper
Skin Pharmacol Appl Skin Physiol 2007;20:195–198
(DOI:10.1159/000101389)

Follicular Penetration of Topically Applied Caffeine via a Shampoo Formulation

Otberg N. · Teichmann A. · Rasuljev U. · Sinkgraven R. · Sterry W. · Lademann J.
aCenter of Experimental and Applied Cutaneous Physiology, Department of Dermatology, Charité-Universitätsmedizin Berlin, Berlin, Germany; bArifov Institute of Electronics, Uzbek Academy of Sciences, Tashkent, Uzbekistan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/5/2006
Accepted: 2/6/2007
Published online: 3/29/2007

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

Aims: Follicular drug delivery is the prerequisite for an effective treatment of androgenetic alopecia or other reasons of premature hair loss. Methods: The follicular penetration of caffeine, applied topically in a shampoo formulation for 2 min, was measured with highly sensitive surface ionization in combination with mass spectroscopy, a selective method for the detection of very small quantities of transcutaneously absorbed substances in the blood. An experimental protocol, developed to selectively block the follicular pathway within the test area, was used. Based on this principle, a clear distinction between interfollicular and follicular penetration of topically applied caffeine was feasible. Results: After 2 min, caffeine penetrated via the hair follicles and stratum corneum. Conclusion: It was found that the penetration via hair follicles was faster and higher compared with the interfollicular route and that hair follicles are the only pathway for fast caffeine absorption during the first 20 min after application.


  

Author Contacts

Dr. Alexa Teichmann
Center of Experimental and Applied Physiology, Department of Dermatology
Charité-Universitätsmedizin Berlin, Charitéplatz 1
DE–10117 Berlin (Germany)
Tel. +49 30 450 518 106, Fax +49 30 450 518 918, E-Mail alexa.teichmann@charite.de

  

Article Information

Received: October 5, 2006
Accepted after revision: February 6, 2007
Published online: March 29, 2007
Number of Print Pages : 4
Number of Figures : 1, Number of Tables : 0, Number of References : 20

  

Publication Details

Skin Pharmacology and Physiology (Journal of Pharmacological and Biophysical Research)

Vol. 20, No. 4, Year 2007 (Cover Date: June 2007)

Journal Editor: Lademann, J. (Berlin)
ISSN: 1660–5527 (print), 1660–5535 (Online)

For additional information: http://www.karger.com/SPP


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/5/2006
Accepted: 2/6/2007
Published online: 3/29/2007

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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