Possible Novel Receptor for PGD2 on Human Bronchial Epithelial CellsChiba T. · Kanda A. · Ueki S. · Ito W. · Yamaguchi K. · Kamada Y. · Takeda M. · Tanigai T. · Oyamada H. · Kayaba H. · Chihara J.
Department of Clinical and Laboratory Medicine, Akita University School of Medicine, Akita, Japan
Prostaglandin D2 (PGD2), a major prostanoid produced by activated mast cells, has long been implicated in allergic diseases. Recent studies have shown that PGD2 exerts its effects through two different G-protein-coupled receptors (GPCRs), the D-prostanoid receptor (DP) and the chemoattractant receptor-homologous molecule expressed on T helper type-2 cells (CRTH2), expressed in various human tissues. The PGD2/CRTH2 system mediates the chemotaxis of eosinophils, basophils, and Th2 cells, which are involved in the induction of allergic inflammation. We have reported that normal human bronchial epithelial cells (NHBE) and epithelial cell lines (NCI-H292) expressed CRTH2, and PGD2 induces production of IL-8 and GM-CSF. This review discusses the role of CRTH2/DP on epithelial cells and mentions a possible novel receptor for PGD2.
Correspondence to: Dr. Junichi Chihara
Department of Clinical and Laboratory Medicine
Akita University School of Medicine, 1-1-1, Hondo
Akita 010-8543 (Japan)
Tel. +81 18 884 6180, Fax +81 18 836 2624, E-Mail firstname.lastname@example.org
Published online: May 31, 2007
Number of Print Pages : 5
Number of Figures : 2, Number of Tables : 0, Number of References : 33
International Archives of Allergy and Immunology
Vol. 143, No. Suppl. 1, Year 2007 (Cover Date: June 2007)
Journal Editor: Valenta, R. (Vienna)
ISSN: 1018–2438 (print), 1423–0097 (Online)
For additional information: http://www.karger.com/IAA