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Original Research Article

Subtle Attentional Deficits in the Absence of Dementia Are Associated with an Increased Risk of Post-Operative Delirium

Lowery D.P. · Wesnes K. · Ballard C.G.

Author affiliations

University of Newcastle upon Tyne, Newcastle upon Tyne, UK

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Dement Geriatr Cogn Disord 2007;23:290–294

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: February 24, 2006
Accepted: April 11, 2006
Published online: March 29, 2007
Issue release date: May 2007

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 1

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Background: Previously, key studies of the risk profile for post-surgical delirium have focused on general medical and non-elective patients, few have examined elective cohorts. Accurate prediction is imperative for clinical trials and prevention strategies. Aims/Hypothesis: Our hypothesis was that subtle pre-operative impairments of attention will be associated with risk of post-operative delirium. Method: A prospective study evaluating pre- and post-operative neuropsychological performance in older (≧70) consecutive elective admissions for orthopaedic surgery, and free of dementia (n = 100) was initiated in a general medical hospital. Results: Pre-operative attentional deficits were closely associated with delirium. Patients who developed post-surgical delirium had significantly slower mean reaction times (p ≤ 0.011) and greater variability of reaction time (p = 0.017). A 4- to 5-fold increased risk of delirium was observed for people one standard deviation above the sample means on these variables. Conclusions: The present study describes a measurement of attentional performance which could form the basis of a neuropsychological marker of delirium.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: February 24, 2006
Accepted: April 11, 2006
Published online: March 29, 2007
Issue release date: May 2007

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 1

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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