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Review

Chronic Myeloproliferative Disorders: The Role of Tyrosine Kinases in Pathogenesis, Diagnosis and Therapy

Macdonald D.a · Cross N.C.b

Author affiliations

aDepartment of Haematology, Imperial College, London, and bWessex Regional Genetics Laboratory, University of Southampton, Salisbury Hospital, Salisbury, UK

Corresponding Author

Donald Macdonald

Room 1L05, Charing Cross Hospital

Fulham Palace Road

London W6 8RF (UK)

Tel. +44 208 846 7122, Fax +44 208 846 7111, E-Mail d.h.macdonald@imperial.ac.uk

Related Articles for ""

Pathobiology 2007;74:81–88

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Abstract

The term chronic myeloproliferative disorders was originally used by Damashek to describe the link amongst a group of acquired blood diseases. Recent molecular genetic analysis has provided a scientific basis for this observation. Underlying myeloproliferative disorders are acquired abnormalities of tyrosine kinase genes. These may be chromosomal translocations resulting in the creation of a fusion kinase gene, examples of which include ABL, FGFR, and PDGFR as seen in disorders CML, 8p11 myeloproliferative syndrome, atypical CML and chronic eosinophilic leukaemia. The second group of tyrosine kinase abnormalities are point mutations in JAK2, a cytosolic TK. This abnormality is seen in 30–97% of cases of MPD with the phenotype PV, ET or CIMF.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Review

Received: October 09, 2006
Accepted: January 02, 2007
Published online: June 25, 2007
Issue release date: June 2007

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 1

ISSN: 1015-2008 (Print)
eISSN: 1423-0291 (Online)

For additional information: http://www.karger.com/PAT


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