Soluble HLA-G and Embryo Implantation: Frequently Asked QuestionsLe Bouteiller P. · Tabiasco J. · Parinaud J.
aINSERM U563, Hôpital Purpan, Toulouse, and bLaboratoire de Biologie de la Reproduction, Hôpital Paule de Viguier, Toulouse, France
Two major criteria are currently used for optimal human embryo selection in in vitro fertilization or intracytoplasmic sperm injection: overall morphology-based grading system and rate of fragmentation. The measurement of soluble HLA-G (sHLA-G) in human preimplantation embryo culture supernatants gives great hope that addition of such a biochemical quantitative criterion would further improve the rates of implantation. In this short review, we will examine the functional significance of this latter approach by discussing the following frequently asked questions: (1) Which sHLA-G isoform(s) might be present in the human preimplantation embryo culture supernatants? (2) Where do these sHLA-G molecules come from? (3) Why are some preimplantation embryos ‘HLA-G secretors’ and others not? (4) How might the functions exerted by sHLA-G molecules influence embryonic implantation?
Philippe Le Bouteiller
INSERM U563, Bât. A, Hôpital Purpan, BP 3028
FR–31024 Toulouse Cedex 3 (France)
Tel. +33 562 748 374, Fax +33 562 744 558
P. Le Bouteiller’s team is member of the European Union Network of Excellence EMBIC.
Published online: October 4, 2007
Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 0, Number of References : 34
Gynecologic and Obstetric Investigation
Vol. 64, No. 3, Year 2007 (Cover Date: October 2007)
Journal Editor: D'Hooghe, T. (Leuven)
ISSN: 0378–7346 (print), 1423–002X (Online)
For additional information: http://www.karger.com/GOI