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Vol. 10, No. 3, 2007
Issue release date: June 2007
Section title: Commentary
Community Genet 2007;10:181–185
(DOI:10.1159/000101760)

The Emergence of Biobanks: Practical Design Considerations for Large Population-Based Studies of Gene-Environment Interactions

Davis R.L.a, b, c · Khoury M.J.a
aOffice of Genomics and Disease Prevention, Centers for Disease Control and Prevention, Atlanta, Ga., bCenter for Health Studies, Group Health Cooperative and cDepartments of Epidemiology and Pediatrics, University of Washington, Seattle, Wash., USA

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Article / Publication Details

First-Page Preview
Abstract of Commentary

Published online: 6/18/2007
Issue release date: June 2007

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 1662-4246 (Print)
eISSN: 1662-8063 (Online)

For additional information: http://www.karger.com/PHG

Abstract

The completion of the human genome project has spurred new thinking about launching large-scale cohort studies; as proposed, these studies will differ from past large-scale cohort studies and will focus primarily on how genetic variation interacts with environmental exposures to affect the risk for common human diseases. There is no single ‘best design’ for large-scale studies of gene-environment interactions. Some studies are best performed in cohort studies where unbiased information can be collected on individuals years before disease onset. Other studies may be most efficiently done with a case-control design using currently available automated data. Population-based biobanks with nested case-control or case-cohort studies offer distinct advantages to some of the resource-intensive large-scale cohort studies under consideration, and may be more acceptable to many of the countries around the world currently considering such projects.

© 2007 S. Karger AG, Basel


  

Author Contacts

Dr. Robert L. Davis
Office of Genomics and Disease Prevention
Centers for Disease Control and Prevention
4770 Buford Highway, Mailstop K-89, Atlanta, GA 30341 (USA)
Tel. +1 770 488 8391, E-Mail rad2@cdc.gov

  

Article Information

Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 2, Number of References : 13

  

Publication Details

Community Genetics

Vol. 10, No. 3, Year 2007 (Cover Date: June 2007)

Journal Editor: ten Kate, L.P. (Amsterdam)
ISSN: 1422–2795 (print), 1422–2833 (Online)

For additional information: http://www.karger.com/CMG


Article / Publication Details

First-Page Preview
Abstract of Commentary

Published online: 6/18/2007
Issue release date: June 2007

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 1662-4246 (Print)
eISSN: 1662-8063 (Online)

For additional information: http://www.karger.com/PHG


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