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Vol. 44, No. 4, 2007
Issue release date: June 2007
Section title: Research Paper
J Vasc Res 2007;44:303–312
(DOI:10.1159/000101776)

Neuregulin-1 Attenuates Neointimal Formation following Vascular Injury and Inhibits the Proliferation of Vascular Smooth Muscle Cells

Clement C.M. · Thomas L.K. · Mou Y. · Croslan D.R. · Gibbons G.H. · Ford B.D.
aDepartment of Anatomy and Neurobiology, Neuroscience Institute, and bDepartment of Medicine, Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, Ga., USA

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Article / Publication Details

First-Page Preview
Abstract of Research Paper

Received: 10/18/2006
Accepted: 1/16/2007
Published online: 4/16/2007

Number of Print Pages: 10
Number of Figures: 6
Number of Tables: 0

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR

Abstract

Neuregulin-1 (NRG-1) is expressed in vascular endothelial cells, and its receptors are localized to the underlying smooth muscle cells. However, the role of NRG-1 in vascular function and injury is largely unknown. First, the expression of NRG-1 and its receptors (erbB receptors) was analyzed after balloon injury to the rat carotid artery. NRG-1 and erbB expression levels were low in uninjured vessels; however, NRG-1 and erbB4 were upregulated following injury. We then examined the effect of NRG-1 on neointimal formation following balloon injury. NRG-1 was administered by tail-vein injection prior to injury and every 2 days following injury. Two weeks after injury, NRG-1-treated animals demonstrated a 50% reduction in lesion size compared with controls receiving the vehicle. To examine possible mechanisms for NRG-1 action, we examined its effects on vascular smooth muscle cell (VSMC) function. Rat VSMC cultures were pretreated with NRG-1 for 24 h and then stimulated with platelet-derived growth factor. NRG-1 significantly decreased platelet-derived growth factor-stimulated VSMC proliferation and migration. These findings suggest that NRG-1 may be a novel therapeutic candidate for the treatment of restenosis and atherosclerosis.


  

Author Contacts

Dr. Byron D. Ford
Department of Anatomy and Neurobiology, Neuroscience Institute
Morehouse School of Medicine, 720 Westview Drive, SW, MRC 222
Atlanta, GA 30310 (USA)
Tel. +1 404 756 5222, Fax +1 404 752 1041, E-Mail bford@msm.edu

  

Article Information

Received: October 18, 2006
Accepted after revision: January 16, 2007
Published online: April 16, 2007
Number of Print Pages : 10
Number of Figures : 6, Number of Tables : 0, Number of References : 38

  

Publication Details

Journal of Vascular Research (Incorporating 'International Journal of Microcirculation')

Vol. 44, No. 4, Year 2007 (Cover Date: June 2007)

Journal Editor: Pohl, U. (Munich)
ISSN: 1018–1172 (print), 1423–0135 (Online)

For additional information: http://www.karger.com/JVR


Article / Publication Details

First-Page Preview
Abstract of Research Paper

Received: 10/18/2006
Accepted: 1/16/2007
Published online: 4/16/2007

Number of Print Pages: 10
Number of Figures: 6
Number of Tables: 0

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR


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