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Vol. 4, No. 2-3, 2007
Issue release date: June 2007
Section title: Paper
Neurodegenerative Dis 2007;4:164–170
(DOI:10.1159/000101841)

Increased Aβ Production Leads to Intracellular Accumulation of Aβ in Flotillin-1-Positive Endosomes

Rajendran L. · Knobloch M. · Geiger K.D. · Dienel S. · Nitsch R. · Simons K. · Konietzko U.
aMax Planck Institute of Molecular Cell Biology and Genetics, and bNeuropathology, Uniklinikum, Techincal University of Dresden, Dresden, Germany; cPsychiatry Research, University of Zurich, Zurich, Switzerland

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 7/27/2006
Accepted: 7/12/2006
Published online: 6/29/2007

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 0

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: http://www.karger.com/NDD

Abstract

Extracellular accumulation of Aβ in β-amyloid plaques is thought to be associated with the neurodegeneration observed in Alzheimer’s disease (AD) patients, although a lack of correlation with cognitive decline raised doubts on this hypothesis. In different transgenic mouse models Aβ accumulates inside the cells and mice develop behavioral deficits well before visible extracellular β-amyloid accumulation. Here we show that intracellular Aβ accumulates in flotillin-1 positive endocytic vesicles. We also demonstrate that flotillin-1 is not only associated with intracellular Aβ in transgenic mice but also with extracellular β-amyloid plaques in AD patient brain sections.


  

Author Contacts

Uwe Konietzko
August Forel-Strasse 1
CH–8008 Zürich (Switzerland)
Tel. +41 44 634 8875, E-Mail uwekon@bli.unizh.ch

  

Article Information

Lawrence Rajendran and Marlen Knobloch contributed equally to the work and hence should be considered equal first authors. Kai Simons and Uwe Konietzko contributed equally to the work and hence should be considered equal senior authors.

Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 0, Number of References : 28

  

Publication Details

Neurodegenerative Diseases

Vol. 4, No. 2-3, Year 2007 (Cover Date: June 2007)

Journal Editor: Nitsch, R.M. (Zürich)
ISSN: 1660–2854 (print), 1660–2862 (Online)

For additional information: http://www.karger.com/NDD


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 7/27/2006
Accepted: 7/12/2006
Published online: 6/29/2007

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 0

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: http://www.karger.com/NDD


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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