Increased Aβ Production Leads to Intracellular Accumulation of Aβ in Flotillin-1-Positive EndosomesRajendran L.a · Knobloch M.c · Geiger K.D.b · Dienel S.a · Nitsch R.c · Simons K.a · Konietzko U.c
aMax Planck Institute of Molecular Cell Biology and Genetics, and bNeuropathology, Uniklinikum, Techincal University of Dresden, Dresden, Germany; cPsychiatry Research, University of Zurich, Zurich, Switzerland
Extracellular accumulation of Aβ in β-amyloid plaques is thought to be associated with the neurodegeneration observed in Alzheimer’s disease (AD) patients, although a lack of correlation with cognitive decline raised doubts on this hypothesis. In different transgenic mouse models Aβ accumulates inside the cells and mice develop behavioral deficits well before visible extracellular β-amyloid accumulation. Here we show that intracellular Aβ accumulates in flotillin-1 positive endocytic vesicles. We also demonstrate that flotillin-1 is not only associated with intracellular Aβ in transgenic mice but also with extracellular β-amyloid plaques in AD patient brain sections.
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Lawrence Rajendran and Marlen Knobloch contributed equally to the work and hence should be considered equal first authors. Kai Simons and Uwe Konietzko contributed equally to the work and hence should be considered equal senior authors.
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 0, Number of References : 28
Vol. 4, No. 2-3, Year 2007 (Cover Date: June 2007)
Journal Editor: Nitsch, R.M. (Zürich)
ISSN: 1660–2854 (print), 1660–2862 (Online)
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