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Table of Contents
Vol. 92, No. 3, 2007
Issue release date: September 2007
Section title: Original Paper
Neonatology 2007;92:205–208
(DOI:10.1159/000102096)

Nucleated Red Blood Cells in Term Fetuses: Reference Values Using an Automated Analyzer

Rolfo A.a · Maconi M.b · Cardaropoli S.a · Biolcati M.a · Danise P.c · Todros T.a
aDepartment of Obstetrics and Gynecology, University of Turin, Turin, bDepartment of Clinical Pathology, AO Arcispedale Santa Maria Nuova, Reggio Emilia, and cDepartment of Oncology Hematology, ASL Salerno 1, Salerno, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 04, 2006
Accepted: January 15, 2007
Published online: April 30, 2007
Issue release date: September 2007

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 1

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO

Abstract

Background: Nucleated red blood cells (NRBCs) are present in small numbers in the cord blood of healthy fetuses at birth. Acute and chronic stimuli, such as fetal hypoxia, cause increased circulating levels of NRBCs. Manual counting is presently the only way to quantify NRBCs, but it is time-consuming and inaccurate. Recently, automated approaches have been developed in order to quantify NRBCs. Objectives: Our aim was to compare manual vs. automated NRBC counting and derive reference values in umbilical cord blood samples from healthy term fetuses. Methods: We analyzed blood samples from 131 healthy term fetuses by the automated approach and calculated reference values of NRBC counts as percentiles. To compare automated NRBC count with manual count we obtained umbilical cord blood samples from 50 further fetuses. Results: Significant positive correlation was obtained between the two methods (r2 = 0.988, Bland-Altman plot mean difference NRBCs/100 WBC: –0.590). The median for NRBCs/100 WBC was 3.05 (range 0–11.6) and the median for absolute NRBC counts ×109/l was 0.39 (range 0–1.8). Conclusions: We demonstrate that values obtained with the automated NRBC counting method are comparable to those obtained with the microscopic manual evaluation and give reference values for umbilical cord NRBCs at term that can be used in clinical practice.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 04, 2006
Accepted: January 15, 2007
Published online: April 30, 2007
Issue release date: September 2007

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 1

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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