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Vol. 28, No. 3, 2007
Issue release date: August 2007
Section title: Original Paper
Neuroepidemiology 2007;28:150–154
(DOI:10.1159/000102143)

Validity of Stroke Diagnoses in a National Register of Patients

Krarup L.-H. · Boysen G. · Janjua H. · Prescott E. · Truelsen T.
aDepartment of Neurology, Copenhagen University Hospital Bispebjerg, and bDanish Epidemiology Science Center at the Institute of Preventive Medicine of Copenhagen, Copenhagen, Denmark

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/25/2006
Accepted: 2/14/2007
Published online: 5/3/2007

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 1

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED

Abstract

Background: Many registers containing routine medical information have been developed for research and surveillance purposes. In epidemiological research assessment of endpoints is often conducted via registers. In the present study we validated stroke and transient ischemic attack (TIA) diagnoses in the Danish National Register of Patients (DNRP). Methods: Subjects from a Danish cohort study, the Copenhagen City Heart Study (n = 19,698), were crosslinked with the DNRP. The following International Classification of Disease 10th revision codes were used to identify possible strokes and TIAs: I60–I69 and G45. Two independent raters reviewed all cases. Positive predictive values of stroke, TIA and stroke subtypes were estimated by dividing the confirmed cases by the total number of cases located in the DNRP. Interrater reliability was tested using ĸ statistics. Results: Of 236 possible cerebrovascular events, 1 in 6 stroke diagnoses did not meet study criteria. The majority of events in the DNRP were registered as unspecified stroke (I64), n = 105 (44%), of which two thirds were diagnosed as ischemic stroke events by the raters. Intracerebral hemorrhage and ischemic stroke had a positive predictive value from 74 to 97%, respectively. Conclusion: Our results show that the DNRP tends to overestimate the number of cerebrovascular events, while ischemic stroke is underestimated.


  

Author Contacts

Lars-Henrik Krarup, MD
Ulstrupvej 2a, 1
DK–2650 Hvidovre (Denmark)
Tel. +45 35 312 754, Fax +45 35 316 112, E-Mail Lh.krarup@gmail.com

  

Article Information

Published online: May 3, 2007
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 1, Number of References : 21

  

Publication Details

Neuroepidemiology

Vol. 28, No. 3, Year 2007 (Cover Date: August 2007)

Journal Editor: Román, G.C. (San Antonio, Tex.)
ISSN: 0251–5350 (print), 1423–0208 (Online)

For additional information: http://www.karger.com/NED


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/25/2006
Accepted: 2/14/2007
Published online: 5/3/2007

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 1

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED


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