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Cover

IgA Nephropathy Today

Editor(s): Tomino Y. (Tokyo) 
Table of Contents
Vol. 157, No. , 2007
Section title: Paper
Tomino Y (ed): IgA Nephropathy Today. Contrib Nephrol. Basel, Karger, 2007, vol 157, pp 94-98
(DOI:10.1159/000102310)

A Multicenter Prospective Cohort Study of Tonsillectomy and Steroid Therapy in Japanese Patients with IgA Nephropathy: A 5-Year Report

Miyazaki M.a · Hotta O.a · Komatsuda A.b · Nakai S.c · Shoji T.d · Yasunaga C.e · Taguma Y.a
aDepartment of Nephrology, Sendai Shakaihoken Hospital, Sendai; b Third Department of Internal Medicine, Akita University School of Medicine, Akita; c Department of Nephrology, Osaka General Medical Center, Osaka; d Department of In-Home Medicine, Nagoya University School of Medicine, Nagoya; e The Kidney Center, Saiseikai Yahata Hospital, Kitakyusyu, Japan

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: May 02, 2007
Cover Date: 2007

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8286-5 (Print)
eISBN: 978-3-318-01467-9 (Online)

Abstract

Tonsillectomy combined with corticosteroids has been performed for IgA nephropathy (IgAN) mainly in Japan. We, the Japanese Multicenter Study Group on the Treatment of IgA Nephropathy (JST-IgAN), have conducted a multicenter prospective cohort study including the combination therapy from 1999. A total of 101 patients (43 male, 58 female) were observed for 5 years. Their average age was 34.4 ± 11.8 (15-55). Subjects were classified by daily proteinuria (UP) and serum creatinine (sCr); UP excreted below 0.5 g/day was defined as stage 1, 0.5-1.0g/da y defined as stage 2, more than 1.0g/da y and sCr ≤1.2 mg/dl in females or ≤1.4 mg/dl in males defined as stage 3, and sCr >1.2 mg/dl in females or >1.4 mg/dl in male defined as stage 4. Both tonsillectomy and high-dose corticosteroid were performed in 75 patients. Of these, 29 patients were stage 1, 26 were stage 2, 16 were stage 3, and 4 were stage 4. The number of subjects with steroid monotherapy were 1 (stage 1), 7 (stage 2), 9 (stage 3) and 1 (stage 4). The primary endpoint in this study was normalized urinalysis as clinical remission. The remission rate treated with combined therapy was 86.2% in stage 1, 73.1% in stage 2, and 43.8% in stage 3. On the other hand, it was 71.4% in stage 2, and 11.1% in stage 3 in steroid monotherapy subjects. Although the number in each treatment group varied because of the non-randomized study, tonsillectomy combined with 3 courses of high-dose corticosteroid therapy was more effective for clinical remission in the higher proteinuria group. We concluded that the goal should be cure and release from disease at an earlier stage of IgAN.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: May 02, 2007
Cover Date: 2007

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8286-5 (Print)
eISBN: 978-3-318-01467-9 (Online)


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.