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Vol. 39, No. 4, 2007
Issue release date: June 2007
Section title: Original Paper
Eur Surg Res 2007;39:251–257
(DOI:10.1159/000102590)

Use of the Hemostatic Agent QuikClot® for the Treatment of Massive Splenic Injury in a Rat Model

Mahajna A. · Hirsh M. · Krausz M.M.
Department of Surgery A and Laboratory of Shock and Trauma Research, Rambam Medical Center, and Technion – Israel Institute of Technology, Haifa, Israel

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/22/2006
Accepted: 11/3/2006
Published online: 5/10/2007
Issue release date: June 2007

Number of Print Pages: 7
Number of Figures: 5
Number of Tables: 0

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: http://www.karger.com/ESR

Abstract

Background: In the present study, QuikClot®(QC) was used to treat intra-abdominal bleeding induced by massive splenic injury (MSI) in rats. Study Design: 40 animals were divided into five groups: (1) sham operated; (2) MSI untreated; (3) MSI treated with 41.5 ml/kg lactated Ringer’s solution (RL); (4) MSI treated with QC, and (5) MSI treated with QC and RL. Results: Untreated MSI was followed by mortality of 60%, total blood loss (TBL) of 33.69% and mean survival time (MST) of 153.9 min. MSI treatment with RL resulted in mortality of 100%, TBL of 61.8% (p < 0.001), and MST of 92.2 min (p < 0.05). MSI treated with QC was followed by TBL of 14.1% (p < 0.005) and MST of 237.5 min (p < 0.05) with no mortality. MSI treated by QC and RL led TBL of 27.4% (p < 0.001 vs. group 3), and MST of 233.3 min (p < 0.05) and no mortality. Conclusions: QC significantly reduced blood loss from the injured spleen with improved survival. Combination of RL and QC prevented the increase in blood loss and improved survival compared to RL alone.

© 2007 S. Karger AG, Basel


  

Author Contacts

Michael M. Krausz, MD
Department of Surgery A, Rambam Medical Center
POB 9602, IL–31096 Haifa (Israel)
Tel. +972 4 854 2782, Fax +972 4 854 3273
E-Mail m_Krausz@rambam.health.gov.il

  

Article Information

Received: May 22, 2006
Accepted after revision: November 3, 2006
Published online: May 10, 2007
Number of Print Pages : 7
Number of Figures : 5, Number of Tables : 0, Number of References : 33

  

Publication Details

European Surgical Research (Clinical and Experimental Surgery)

Vol. 39, No. 4, Year 2007 (Cover Date: June 2007)

Journal Editor: Kempski, O. (Mainz)
ISSN: 0014–312X (print), 1421–9921 (Online)

For additional information: http://www.karger.com/ESR


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/22/2006
Accepted: 11/3/2006
Published online: 5/10/2007
Issue release date: June 2007

Number of Print Pages: 7
Number of Figures: 5
Number of Tables: 0

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: http://www.karger.com/ESR


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