Journal Mobile Options
Table of Contents
Vol. 79, No. 1, 2007
Issue release date: July 2007
Section title: Original Paper
Urol Int 2007;79:44–49
(DOI:10.1159/000102913)

DNA Variation in MSR1, RNASEL and E-Cadherin Genes and Prostate Cancer in Poland

Cybulski C. · Wokołorczyk D. · Jakubowska A. · Gliniewicz B. · Sikorski A. · Huzarski T. · Dębniak T. · Narod S.A. · Lubiński J.
aInternational Hereditary Cancer Center, Department of Genetics and Pathology and bClinic of Urology, Pomeranian Medical University, Szczecin, Poland; cCentre for Research on Women’s Health, Toronto, Ont., Canada

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Automatic perpetual access to all articles of the subscribed year(s)
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/7/2006
Accepted: 11/10/2006
Published online: 7/12/2007

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN

Abstract

Introduction: We investigated whether or not inherited variation in MSR1, RNASEL and E-cadherin contribute to prostate cancer risk in Poland. Material and Methods: We sequenced the coding region of these three genes in individuals from Poland and identified five common DNA variants (R462Q and D541E in RNASEL, R293X and P275A in MSR1, and 2076C>T (A692A) in E-cadherin). These five variants and the –160C>A promoter change in E-cadherin were genotyped in 737 prostate cancer cases and 511 controls. Results: The frequencies of genotyped variants in MSR1, RNASEL and E-cadherin genes in cases and controls were similar. We did not see any association for the studied variants when cases were stratified by age of diagnosis, by family history, by prostate-specific antigen level at the time of diagnosis, by Gleason sore or by tumor stage. Conclusions: Inherited variation in RNASEL, MSR1 and E-cadherin genes do not seem to contribute to prostate cancer development in Poland.


  

Author Contacts

Cezary Cybulski
International Hereditary Cancer Center, Department of Genetics and Pathology
Pomeranian Medical University, ul. Połabska 4
PL–70-115 Szczecin (Poland)
Tel. +48 91 466 1532, Fax +48 91 466 1533, E-Mail cezarycy@sci.pam.szczecin.pl

  

Article Information

Received: July 7, 2006
Accepted: October 11, 2006
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 2, Number of References : 34

  

Publication Details

Urologia Internationalis

Vol. 79, No. 1, Year 2007 (Cover Date: July 2007)

Journal Editor: Hakenberg, O.W. (Rostock)
ISSN: 0042–1138 (print), 1423–0399 (Online)

For additional information: http://www.karger.com/UIN


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/7/2006
Accepted: 11/10/2006
Published online: 7/12/2007

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.