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Vol. 80, No. 1, 2007
Issue release date: June 2007
Section title: Original Paper
Pharmacology 2007;80:49–56
(DOI:10.1159/000103097)

Behavioral Evaluation of Male and Female Mice Pups Exposed to Fluoxetine during Pregnancy and Lactation

Lisboa S.F.S. · Oliveira P.E. · Costa L.C. · Venâncio E.J. · Moreira E.G.
Departments of aPhysiological Sciences and bPathological Sciences, State University of Londrina, Londrina, Brazil

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/27/2006
Accepted: 1/3/2007
Published online: 5/23/2007

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 6

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA

Abstract

Background/Aims: Fluoxetine (FLX) has been widely prescribed for depression during pregnancy and/or lactation. Since serotonin is a neurotrophic factor, the use of FLX by mothers could disrupt brain development resulting in behavioral alterations in their progeny. This study evaluated the effects of developmental FLX exposure on anxiety, depression, aggressivity and pain sensitivity of male and female mice pups. Methods: Swiss dams were treated daily, by gavage, with 7.5 mg/kg of FLX during pregnancy and lactation. Pups were submitted to open-field, forced swimming, elevated plus-maze, intruder-resident and hot plate tests at adolescence and adulthood. Results and Conclusion: In male pups, exposure to FLX decreased ambulation at postnatal day (PND) 40 and tended (p = 0.07) to increase the latency to the first attack in the intruder-resident test at PND 70, suggesting decreased impulsivity. In female pups, FLX exposure increased immobility time in the forced swimming test at both PND 30 and 70, which is interpreted as depressive-like behavior. In conclusion, our results suggest that maternal exposure to FLX during pregnancy and lactation results in enduring behavioral alterations in male and female pups throughout life.


  

Author Contacts

Estefânia G. Moreira
CP 6016
86051-980 Londrina, PR (Brazil)
Tel. +55 43 3371 4307, Fax +55 43 3371 4467
E-Mail egmoreira@uel.br

  

Article Information

Received: November 27, 2006
Accepted: January 3, 2007
Published online: May 23, 2007
Number of Print Pages : 8
Number of Figures : 1, Number of Tables : 6, Number of References : 44

  

Publication Details

Pharmacology (International Journal of Experimental and Clinical Pharmacology)

Vol. 80, No. 1, Year 2007 (Cover Date: June 2007)

Journal Editor: Donnerer, J. (Graz)
ISSN: 0031–7012 (print), 1423–0313 (Online)

For additional information: http://www.karger.com/PHA


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/27/2006
Accepted: 1/3/2007
Published online: 5/23/2007

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 6

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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