The term Krukenberg tumor refers to
metastatic disease of the ovary, especially those metastases
containing mucin-secreting signet ring cells.
Krukenberg tumor of breast origin is not a frequent condition.
Case Report: A 49-year-old postmenopausal
woman was admitted with pains in her breast, and masses
in both breasts were biopsied. Pathology showed invasive
ductal cancer with mucin-secreting signet ring
cells. X-rays of the spinal column confirmed metastasis
to the thoracic vertebrae, and the patient was found to
have stage 4 breast cancer. Treatment consisted of
chemotherapy, palliative radiotherapy and adjuvant hormone
therapy with tamoxifen. The patient showed good
response to treatment and was stable for 2 years. She
was admitted to our clinic complaining of pelvic pain.
Local recurrence, multicentric bone metastases with a
right adnexal mass and ascites were detected. We performed
total abdominal hysterectomy, bilateral salpingooophorectomy
and appendectomy. The pathological diagnosis
of the tumor revealed metastasis of signet ring
cell breast cancer to the right ovary. The patient was
treated with letrozole 2.5 mg/day and zoledronic acid
4 mg/day and is alive 5 months after surgery. Conclusion:
Even though complete response to chemoradiotherapy
in advanced breast cancer is possible, Krukenberg
tumors of breast origin may be seen in the followup
Copyright / Drug Dosage
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