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Vol. 144, No. 3, 2007
Issue release date: October 2007
Section title: Original Paper
Int Arch Allergy Immunol 2007;144:226–230
(DOI:10.1159/000103996)

Predictive Value of Autologous Plasma Skin Test for Multiple Nonsteroidal Anti-Inflammatory Drug Intolerance

Asero R.
Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/28/2006
Accepted: 3/28/2007
Published online: 6/18/2007

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Background: Recent studies show that patients with multiple nonsteroidal anti-inflammatory drug (NSAID) intolerance are frequently characterized by autoreactivity; this can be detected by autologous serum skin test (ASST). Objective: To assess whether the autologous plasma skin test (APST), a test that was recently shown to be more sensitive than ASST, may be usefully employed as a predictive test for multiple NSAID intolerance in patients with a history of single NSAID intolerance. Methods: Thirty otherwise normal adults with a history of acute urticaria following the ingestion of one single NSAID underwent an APST before being challenged with a COX-1-inhibiting NSAID other than the offending drug. Results: Sixteen patients experienced urticaria following the ingestion of the alternative NSAID and were therefore classified as multiple NSAID reactors; all 16 (100%) scored positive on APST. In contrast only 3/14 patients finally classified as single NSAID reactors were positive on APST (p < 0.001). The positive and negative predictive value of APST for multiple NSAID intolerance were 86 and 100%, respectively. Conclusion: In patients with a history of acute urticaria induced by a single NSAID APST can be usefully employed to detect patients that are prone to react to NSAID other than the original offending one.


  

Author Contacts

Correspondence to: Dr. Riccardo Asero
Ambulatorio di Allergologia, Clinica San Carlo
Via Ospedale 21
IT–20037 Paderno Dugnano (Italy)
Tel. +39 02 9903 8470, Fax +39 02 9903 8223, E-Mail r.asero@libero.it

  

Article Information

Received: December 28, 2006
Accepted after revision: March 28, 2007
Published online: June 18, 2007
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 1, Number of References : 32

  

Publication Details

International Archives of Allergy and Immunology

Vol. 144, No. 3, Year 2007 (Cover Date: October 2007)

Journal Editor: Valenta, R. (Vienna)
ISSN: 1018–2438 (print), 1423–0097 (Online)

For additional information: http://www.karger.com/IAA


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/28/2006
Accepted: 3/28/2007
Published online: 6/18/2007

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


Copyright / Drug Dosage

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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