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Vol. 144, No. 3, 2007
Issue release date: October 2007
Section title: Original Paper
Int Arch Allergy Immunol 2007;144:231–239
(DOI:10.1159/000103997)

Occupational Sensitization to Fungal Enzymes Used in Animal Feed Industry

Caballero M.L. · Gómez M. · González-Muñoz M. · Reinoso L. · Rodríguez-Pérez R. · Alday E. · Moneo I.
aServicio de Inmunología, Hospital Carlos III, y bUnidad de Neumología y Alergia Laboral, Instituto Nacional de Seguridad e Higiene en el Trabajo, Madrid, España

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/12/2006
Accepted: 4/11/2007
Published online: 6/19/2007

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 3

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Background: Industrial enzymes cause the increasing prevalence of occupational hypersensitivity. Our objective was to study workers occupationally exposed to fungal enzymes in 2 animal feed factories to determine if the sensitization originated in the enzymes or was caused by the microorganism used to produce the enzymes. Methods: Eighty-six consenting workers were studied by skin prick tests with extracts from the enzymatic products handled in their factories. Positive workers were then studied by IgE immunoblotting and basophil activation was measured by flow cytometry. Results: Eight of the 86 workers analysed (9%) tested positive and were more frequently sensitized to phytase from Trichoderma and Peniophora. Glucanase and α-amylase from Bacillus amyloliquefaciens did not cause sensitization in any worker. No cross-reactions were observed between Trichoderma and Peniophora sp. phytases. Workers were sensitized to the product that they handled. Conclusions: Fungal enzymes cause occupational hypersensitivity in animal feed industries. Immunoblotting and basophil activation are useful to evaluate the effects of handling enzymes as part of the medical surveillance of enzyme-exposed workers. We describe Peniophora sp. 6-phytase as a new allergen and enzymes from Trichoderma as strong sensitizers.


  

Author Contacts

Correspondence to: Dr. María Luisa Caballero
Hospital Carlos III, C/Sinesio Delgado 10
ES–28029 Madrid (Spain)
Tel. +34 91 453 26 56, Fax +34 91 733 66 14
E-Mail mlcsoto@hotmail.com

  

Article Information

Received: September 12, 2006
Accepted after revision: April 11, 2007
Published online: June 19, 2007
Number of Print Pages : 9
Number of Figures : 4, Number of Tables : 3, Number of References : 20

  

Publication Details

International Archives of Allergy and Immunology

Vol. 144, No. 3, Year 2007 (Cover Date: October 2007)

Journal Editor: Valenta, R. (Vienna)
ISSN: 1018–2438 (print), 1423–0097 (Online)

For additional information: http://www.karger.com/IAA


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/12/2006
Accepted: 4/11/2007
Published online: 6/19/2007

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 3

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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