Journal Mobile Options
Table of Contents
Vol. 34, No. 4, 2007
Issue release date: August 2007
Section title: Review Article · Übersichtsarbeit
Transfus Med Hemother 2007;34:268-275
(DOI:10.1159/000104213)

Cryopreservation of Hematopoietic Stem Cells: Emerging Science, Technology and Issues

Fleming K.K. · Hubel A.
Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN, USA

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Abstract

Cell therapies based on hematopoietic stem cells (HSCs) have become the standard of care for a variety of diseases, and the number of patients and disorders being treated using HSCs continues to grow. Effective methods of preservation are critical for the clinical implementation of HSC-based therapies. Preservation permits the completion of safety and quality control testing, transportation to the site of use and coordination of the therapy with patient care regimes. This review discusses advances in the basic science of preservation that will permit us to improve preservation protocols for HSCs and other cell types. Recent advances in preservation technology can also be used to reduce cell losses during cell processing for preservation and improve the safety of HSCs used therapeutically. Finally, the growth of HSC therapy worldwide has created interest in alternative methods of preservation. This review also includes a discussion of different methods of freezing and storage. Improved methods for preserving HSCs will improve not only therapies based on these cells but can improve and speed development of preservation protocols for other cell types used therapeutically.


Article / Publication Details

First-Page Preview
Abstract of Review Article · Übersichtsarbeit

Published online: 7/31/2007
Issue release date: August 2007

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-3796 (Print)
eISSN: 1660-3818 (Online)

For additional information: http://www.karger.com/TMH


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.