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Vol. 1, No. 1, 2007
Issue release date: 2007
Section title: Published: June 2007

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Case Rep Gastroenterol 2007;1:7–14
(DOI:10.1159/000104225)

Rare Cause of Dysphagy: Giant Polypoid Esophageal Well-Differentiated Liposarcoma

Mica L. · Gianom D. · Bode B. · Jaklin P. · Hollinger A.
Departments of aSurgery and bInternal Medicine, Spital Männedorf, Männedorf, and cInstitute of Surgical Pathology, University Hospital of Zürich, Zürich, Switzerland

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Abstract

Liposarcoma represents one of the most frequent (10–20%) malignant mesenchymal tumors in the adult, affecting mostly the soft tissue of extremities, the trunk or the retroperitoneum. This tumor type occurs exceptionally rarely in the gastrointestinal tract with only few cases described in the literature. In this case we present a 73-year-old male patient who was admitted due to loss of weight, anorexia and postprandial emesis with dysphagy. Gastrographin esophagography failed to make precise diagnostics. CT scan of the upper gastrointestinal tract revealed a large esophageal tumor filling out the whole length of the esophagus. The tumor was removed by parasternocleidomastoidal approach with a stapler. Histopathological examination revealed a well-differentiated liposarcoma (grade I). Well-differentiated liposarcomas are characterised by amplified material of the 12q13–15 chromosomal region, present in the form of giant or ring chromosomes and leading to the overexpression of MDM2 and CDK4 genes. MDM2 and CDK4 proteins can be detected immunhistochemically, which was the case in the reported tumor. Overexpression of these proteins leads to suppression of tumor suppressor genes, leading to increased cell survival.


  

Author Contacts

Ladislav Mica, MD
Spital Männedorf
Asylstrasse 10
CH–8708 Männedorf (Switzerland)
Tel. +41 44 922 22 11, E-Mail l.mica@spitalmaennedorf.ch

  

Article Information

Published online: June 20, 2007
Number of Print Pages : 8
Number of Figures : 6, Number of Tables : 0, Number of References : 19

  

Publication Details

Case Reports in Gastroenterology

Vol. 1, No. 1, Year 2007 (Cover Date: 2007)

Journal Editor: Urrutia, R. (Rochester, Minn.)
ISSN: 1662–0631 (print), 1662–0631 (Online)

For additional information: http://www.karger.com/CRG


Article / Publication Details

First-Page Preview
Abstract of Published: June 2007

Published online: 6/20/2007

Number of Print Pages: 8
Number of Figures: 6
Number of Tables: 0

ISSN: (Print)
eISSN: 1662-0631 (Online)

For additional information: http://www.karger.com/CRG


Open Access License / Drug Dosage

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