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Rare Cause of Dysphagy: Giant Polypoid Esophageal Well-Differentiated LiposarcomaMica L.a · Gianom D.a · Bode B.c · Jaklin P.b · Hollinger A.a
Departments of aSurgery and bInternal Medicine, Spital Männedorf, Männedorf, and cInstitute of Surgical Pathology, University Hospital of Zürich, Zürich, Switzerland Corresponding Author
Ladislav Mica, MD
CH–8708 Männedorf (Switzerland)
Tel. +41 44 922 22 11, E-Mail firstname.lastname@example.org
Liposarcoma represents one of the most frequent (10–20%) malignant mesenchymal tumors in the adult, affecting mostly the soft tissue of extremities, the trunk or the retroperitoneum. This tumor type occurs exceptionally rarely in the gastrointestinal tract with only few cases described in the literature. In this case we present a 73-year-old male patient who was admitted due to loss of weight, anorexia and postprandial emesis with dysphagy. Gastrographin esophagography failed to make precise diagnostics. CT scan of the upper gastrointestinal tract revealed a large esophageal tumor filling out the whole length of the esophagus. The tumor was removed by parasternocleidomastoidal approach with a stapler. Histopathological examination revealed a well-differentiated liposarcoma (grade I). Well-differentiated liposarcomas are characterised by amplified material of the 12q13–15 chromosomal region, present in the form of giant or ring chromosomes and leading to the overexpression of MDM2 and CDK4 genes. MDM2 and CDK4 proteins can be detected immunhistochemically, which was the case in the reported tumor. Overexpression of these proteins leads to suppression of tumor suppressor genes, leading to increased cell survival.
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