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Vol. 24, No. 2, 2007
Issue release date: July 2007
Section title: Original Research Article
Dement Geriatr Cogn Disord 2007;24:98–103
(DOI:10.1159/000104467)

Cognitive Impairment in Alzheimer’s Disease Is Modified by APOE Genotype

van der Vlies A.E. · Pijnenburg Y.A.L. · Koene T. · Klein M. · Kok A. · Scheltens P. · van der Flier W.M.
Departments of aNeurology and Alzheimer Center, bMedical Psychology and cClinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 11/10/2006
Accepted: 7/1/2007
Published online: 6/26/2007

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Aim: We examined whether impairment in specific cognitive domains in Alzheimer’s disease (AD) differed according to APOE genotype and age at onset. Methods: Cognitive functions of 229 consecutive AD patients were assessed using Visual Association Test (VAT), Memory Impairment Screen+ (MIS+), VAT object naming, fluency test and Trail Making Test (TMT). Dementia severity was assessed using MMSE. ANOVAs were performed with APOE genotype and age at onset as independent variables and sex, education and MMSE as covariates. Results: 28% of patients were APOE ε4-negative, 58% heterozygous and 14% homozygous. A significant association between APOE genotype and VAT and MIS+ was found when correcting for sex and education. An interaction effect between APOE genotype and age at onset on VAT and VAT object naming was found, with young carriers performing worse than young noncarriers. By contrast, when additionally correcting for MMSE, a significant association between APOE genotype and VAT object naming, TMT-A and TMT-B was found, with noncarriers performing worse than carriers. Conclusion: Memory was more impaired among APOE ε4 carriers than among noncarriers. By contrast, naming, executive functions and mental speed were more impaired among APOE ε4 noncarriers. This suggests that the APOE genotype modifies the clinical phenotype in terms of cognitive impairment in AD.


  

Author Contacts

A.E. van der Vlies
Department of Neurology and Alzheimer Center, VU University Medical Center
PO Box 7057
NL–1007 MB Amsterdam (The Netherlands)
Tel. +31 20 444 1079, Fax +31 20 444 0715, E-Mail ae.vdvlies@vumc.nl

  

Article Information

Accepted: January 7, 2007
Published online: June 26, 2007
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 2, Number of References : 29

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 24, No. 2, Year 2007 (Cover Date: July 2007)

Journal Editor: Chan-Palay, V. (New York, N.Y.)
ISSN: 1420–8008 (print), 1421–9824 (Online)

For additional information: http://www.karger.com/DEM


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 11/10/2006
Accepted: 7/1/2007
Published online: 6/26/2007

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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