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Vol. 221, No. 5, 2007
Issue release date: August 2007
Section title: Original Paper
Ophthalmologica 2007;221:331–339
(DOI:10.1159/000104764)

Clinicopathological Analysis of Periocular Sebaceous Gland Carcinoma

Yoon J.S. · Kim S.H. · Lee C.S. · Lew H. · Lee S.Y.
aDepartment of Ophthalmology, Institute of Vision Research, and bDepartment of Pathology, Yonsei University College of Medicine, Seoul, and cDepartment of Ophthalmology, Pochun CHA University College of Medicine, Pundang CHA Hospital, Sungnam, South Korea

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/3/2006
Accepted: 10/27/2006
Published online: 8/30/2007

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 3

ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)

For additional information: http://www.karger.com/OPH

Abstract

Background: We analyzed the clinicopathological features and prognosis in patients with periocular sebaceous gland carcinoma. Methods: Retrospectively, we studied the records of 24 cases of sebaceous gland carcinoma treated in our clinic between 1999 and 2004. The reviewed data included demographic information, initial clinical and histopathological diagnosis, anatomic tumor location, details of treatment, tumor involvement of resection margin, and outcomes such as local recurrence, distant metastasis and survival. Results: Local recurrence developed in 6 cases (25%) at a median of 20 months from initial diagnosis. Only 2 patients (8.3%) died of systemic metastasis to brain and bone from primary lacrimal gland carcinoma. The local recurrence rate in the complete excision group (5.9%) was significantly lower compared with the incomplete excision with irradiation group (71.4%; Fisher’s exact test, p = 0.003). We observed a shorter duration of symptom, a higher rate of eventual exenteration and local recurrence, and a shorter time interval to local recurrence from initial management in poorly differentiated tumors compared with moderately differentiated tumors. Conclusion: It is critical to achieve a negative tumor margin in both frozen and permanent section to prevent local recurrence. Early aggressive management is required in sebaceous gland carcinoma of the lacrimal gland, as its mortality is much higher than that of eyelid origin.


  

Author Contacts

Sang Yeul Lee, MD
Department of Ophthalmology, Yonsei University, College of Medicine
Severance Hospital, CPO Box 8044
Seodaemoongu Shinchondong 134, Seoul 120-752 (South Korea)
Tel. +82 2 2228 3570, Fax +82 2 312 0541, E-Mail sylee@yumc.yonsei.ac.kr

  

Article Information

Received: August 3, 2006
Accepted after revision: October 27, 2006
Number of Print Pages : 9
Number of Figures : 4, Number of Tables : 3, Number of References : 35

  

Publication Details

Ophthalmologica (International Journal of Ophthalmology)

Vol. 221, No. 5, Year 2007 (Cover Date: August 2007)

Journal Editor: Ohrloff, C. (Frankfurt a.M.)
ISSN: 0030–3755 (print), 1423–0267 (Online)

For additional information: http://www.karger.com/OPH


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/3/2006
Accepted: 10/27/2006
Published online: 8/30/2007

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 3

ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)

For additional information: http://www.karger.com/OPH


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