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Table of Contents
Vol. 41, No. 5, 2007
Issue release date: August 2007
Section title: Original Paper
Caries Res 2007;41:342–349
(DOI:10.1159/000104791)

The Antibacterial Activity of Plant Extracts Containing Polyphenols against Streptococcus mutans

Smullen J. · Koutsou G.A. · Foster H.A. · Zumbé A. · Storey D.M.
Biomedical Sciences Research Institute, University of Salford, Manchester, UK

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 12, 2006
Accepted: November 24, 2006
Published online: August 22, 2007
Issue release date: August 2007

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 4

ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)

For additional information: http://www.karger.com/CRE

Abstract

The minimum inhibitory concentrations (MIC) of commercially available and 70% aqueous propanone (P70) extracts from plants chosen for polyphenol content on Streptococcus mutans and other bacteria were determined using a standard susceptibility agar dilution technique to investigate their potential use as anticariogenic agents. The effects on adhesion of S. mutans to glass were also studied. The lowest MICs were for the P70 extracts of red grape skin (0.5 mg ml–1) and green tea and sloe berry skin (2 mg ml–1). The commercial extracts generally had a lower activity with a minimum MIC of 2 mg ml–1 for tea extracts, grape seed extracts and Pynogenol® (extract of maritime pine). All other extracts had MICs of ≧4 mg ml–1. Unfermented cocoa had greater antimicrobial activity than fermented cocoa and the activity of the fractionated extract increased with the extent of epicatechin polymerization. Epicatechin polymer had an MIC of 1 mg ml–1 and an MBC of 64 mg ml–1. Selected extracts were tested against other oral bacteria and showed activity against Gram-positive organisms. P70 extracts of unfermented cocoa, epicatechin polymer fraction, green tea and red grape seed were bacteriostatic and prevented acid production when added at the MIC to cultures of S. mutans grown in a chemically defined medium supplemented with either glucose or sucrose. There was a reduction in viability which was greater when added to washed cells, but there were some viable cells after 24 h. The extracts also reduced adherence of S. mutans to glass.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 12, 2006
Accepted: November 24, 2006
Published online: August 22, 2007
Issue release date: August 2007

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 4

ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)

For additional information: http://www.karger.com/CRE


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