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Vol. 13, No. 5-6, 2006
Issue release date: August 2007
Section title: Paper
Neuroimmunomodulation 2006;13:268–276
(DOI:10.1159/000104854)

HPA and Immune Axes in Stress: Involvement of the Serotonergic System

Leonard B.E.
Pharmacology Department, National University of Ireland, Galway, Ireland; Brain and Behaviour Research Institute, Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, The Netherlands

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 2/9/2007
Accepted: 2/26/2007
Published online: 8/22/2007

Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 0

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM

Abstract

Chronic stress, by initiating changes in the hypothalamic-pituitary-adrenal axis and the immune system, acts as a trigger for anxiety and depression. There is experimental and clinical evidence that the rise in the concentration of pro-inflammatory cytokines and glucocorticoids, which occurs in a chronically stressful situation and also in depression, contributes to the behavioural changes associated with depression. A defect in serotonergic function is associated with these hormonal and immune changes. Neurodegenerative changes in the hippocampus, prefrontal cortex and amygdalae are the frequent outcomes of the changes in the hypothalamic-pituitary-adrenal axis and the immune system. Such changes may provide evidence for the link between chronic depression and dementia in later life.


  

Author Contacts

Brian E. Leonard
National University of Ireland
Galway (Ireland)
Tel. +353 91 52 44 11, ext. 2350, Fax +353 91 52 53 00
E-Mail belucg@iol.ie

  

Article Information

Published online: August 6, 2007
Number of Print Pages : 9
Number of Figures : 2, Number of Tables : 0, Number of References : 69

  

Publication Details

Neuroimmunomodulation

Vol. 13, No. 5-6, Year 2006 (Cover Date: August 2007)

Journal Editor: Savino, W. (Rio de Janeiro)
ISSN: 1021–7401 (print), 1423–0216 (Online)

For additional information: http://www.karger.com/NIM


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 2/9/2007
Accepted: 2/26/2007
Published online: 8/22/2007

Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 0

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM


Copyright / Drug Dosage

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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