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Vol. 30, No. 5, 2007
Issue release date: September 2007
Section title: Original Paper
Kidney Blood Press Res 2007;30:283–288
(DOI:10.1159/000105264)

Pulse Pressure Is an Independent Predictor of Aortic Stiffness in Patients with Mild to Moderate Chronic Kidney Disease

Stancanelli B.a · Malatino L.S.a · Malaponte G.b · Noto P.a · Giuffrè E.a · Caruso A.a · Gagliano C.a · Zoccolo A.M.a · Puccia G.a · Castellino P.a
Departments of aMedicine and Systemic Diseases, and bBiomedical Sciences, University of Catania, Catania, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/2/2007
Accepted: 5/18/2007
Published online: 7/6/2007
Issue release date: September 2007

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 3

ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)

For additional information: http://www.karger.com/KBR

Abstract

Background: In patients with end-stage renal disease pulse wave velocity (PWV) has been widely assessed, but its behavior in mild to moderate chronic kidney disease (CKD) has been less investigated. We evaluated PWV in mild to moderate CKD. Methods: We studied 31 patients with grade II–IV CKD. Aortic PWV (aPWV), aortic and upper limb augmentation index, creatinine clearance, C-reactive protein, serum fibrinogen, interleukin-1, interleukin-6, tumor necrosis factor, albumin, total and high-density lipoprotein cholesterol and blood pressure were evaluated. Results: aPWV (7.95 ± 0.64 m/s), but not augmentation index was significantly higher (p = 0.03) in CKD patients than age-matched healthy subjects (aPWV: 6.24 ± 0.43 m/s; upper limb: 32.8 ± 1.9; aortic: 27.7 ± 1.9). At univariate regression analysis, aPWV was significantly correlated with age (r = 0.44; p = 0.013), interleukin-6 (r = 0.43; p = 0.027), pulse (r = 0.39; p = 0.029), systolic blood pressure (r = 0.37; p = 0.038) and tumor necrosis factor (r = 0.39; p = 0.029). At multivariate analysis, pulse pressure was the only significant independent determinant (β = 0.37; p = 0.05) of aPWV. Conclusion: The results of this study confirm an aPWV increase in mild to moderate CKD and emphasize association between pulse pressure and PWV, independently of renal failure.

© 2007 S. Karger AG, Basel


  

Author Contacts

Prof. Lorenzo S. Malatino
Department of Medicine and Systemic Diseases
Chair and Unit of Internal Medicine and Hypertension Center, University of Catania
c/o Ospedale Civile, IT–97100 Ragusa (Italy)
Tel. +39 0932 600 344, Fax +39 0932 600 217, E-Mail malatino@unict.it

  

Article Information

Received: March 2, 2007
Accepted: May 18, 2007
Published online: July 6, 2007
Number of Print Pages : 6
Number of Figures : 1, Number of Tables : 3, Number of References : 48

  

Publication Details

Kidney and Blood Pressure Research

Vol. 30, No. 5, Year 2007 (Cover Date: September 2007)

Journal Editor: Wanner, C. (Würzburg)
ISSN: 1420–4096 (print), 1423–0143 (Online)

For additional information: http://www.karger.com/KBR


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/2/2007
Accepted: 5/18/2007
Published online: 7/6/2007
Issue release date: September 2007

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 3

ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)

For additional information: http://www.karger.com/KBR


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