Cognitive Performance after Lacunar Stroke Correlates with Leukoaraiosis SeverityMcMurtray A.M. · Liao A. · Haider J. · Licht E. · Mendez M.F.
aDepartments of Neurology and Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at the University of California at Los Angeles, and bV.A. Greater Los Angeles Healthcare System, Los Angeles, Calif., USA
Background: This study investigates the effect of leukoaraiosis on patients presenting with cognitive impairment after lacunar stroke. Methods: Fourty-six patients with cognitive impairment and newly discovered lacunar stroke detected by brain magnetic resonance imaging underwent neuropsychological testing. Results: Patients with both lacunar infarct and leukoaraiosis performed less well on cognitive measures, compared to those with lacunar infarcts alone. Additionally, leukoaraiosis severity inversely correlated with cognitive performance. Conclusions: In patients with lacunar stroke, presence of leukoaraiosis is associated with worse performance in multiple cognitive domains. These findings suggest lacunar infarcts plus leukoaraiosis is a common etiology for vascular dementia.
Neurobehavior Unit (116AF)
V.A. Greater Los Angeles Healthcare System
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Received: February 21, 2007
Accepted: February 23, 2007
Published online: July 17, 2007
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 2, Number of References : 27
Vol. 24, No. 2-3, Year 2007 (Cover Date: August 2007)
Journal Editor: Hennerici, M.G. (Mannheim)
ISSN: 1015–9770 (print), 1421–9786 (Online)
For additional information: http://www.karger.com/CED