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Vol. 65, No. 1, 2008
Issue release date: October 2007
Section title: Original Paper
Hum Hered 2008;65:1–8
(DOI:10.1159/000106057)

A Differential Association of ALOX15 Polymorphisms with Bone Mineral Density in Pre- and Post-Menopausal Women

Cheung C.-L. · Chan V. · Kung A.W.C.
Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, SAR, China

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/5/2007
Accepted: 3/23/2007
Published online: 7/25/2007
Issue release date: October 2007

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 4

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: http://www.karger.com/HHE

Abstract

Objective: The 12/15-lipoxygenase gene ALOX15 is reported to be a negative regulator of BMD in knockout mice. Nonetheless results are controversial as over-expression of ALOX15 protects against inflammation-related bone loss. The aim of the present study is to systematically study the relation of ALOX15 polymorphisms in BMD variation in southern Chinese women. Methods: Ten tag single nucleotide polymorphisms (SNP) were genotyped in 942 subjects with either low BMD (defined by a BMD Z score ≤–1.28 at either the hip or spine) or high BMD (Z score ≧+1). Single locus and haplotype associations were performed using logistic regression with adjustment of age, height and weight. Results: The variant ‘G’ allele of rs2619112 was associated with a reduced risk of low BMD at the femoral neck in pre-menopausal women (OR = 0.442, p = 0.007) but an increased risk in post-menopausal women (OR = 1.727, p = 0.042). Haplotype analysis revealed findings similar to the single locus tests. Conclusion: The variant alleles of rs2619112 and rs916055 and their haplotypes of ALOX15 are associated with high BMD in pre-menopausal women but low BMD in post-menopausal women. This suggests that ALOX15 is a dual modulator of BMD variation with opposing effects in pre- and post-menopausal women.

© 2008 S. Karger AG, Basel


  

Author Contacts

Annie W.C. Kung
Department of Medicine, The University of Hong Kong
Queen Mary Hospital
Hong Kong, SAR (China)
Tel. +852 2855 4769, Fax +852 2816 2187, E-Mail awckung@hkucc.hku.hk

  

Article Information

Received: February 5, 2007
Accepted after revision: March 23, 2007
Published online: July 25, 2007
Number of Print Pages : 8
Number of Figures : 2, Number of Tables : 4, Number of References : 28

  

Publication Details

Human Heredity (International Journal of Human and Medical Genetics)

Vol. 65, No. 1, Year 2008 (Cover Date: October 2007)

Journal Editor: Devoto, M. (Philadelphia, Pa.)
ISSN: 0001–5652 (print), 1423–0062 (Online)

For additional information: http://www.karger.com/HHE


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/5/2007
Accepted: 3/23/2007
Published online: 7/25/2007
Issue release date: October 2007

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 4

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: http://www.karger.com/HHE


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