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Vol. 55, No. 3-4, 2007
Issue release date: October 2007
Section title: Original Paper
Neuropsychobiology 2007;55:167–170
(DOI:10.1159/000106476)

A Preliminary Study of Dopamine Transporter Binding in Bipolar and Unipolar Depressed Patients and Healthy Controls

Amsterdam J.D. · Newberg A.B.
aDepartment of Psychiatry, The Depression Research Unit, and bDepartment of Radiology, Division of Nuclear Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pa., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/22/2006
Accepted: 5/27/2007
Published online: 7/26/2007

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

Objective: We examined striatal dopamine transporter (DAT) binding in bipolar and unipolar depressed patients and compared these values to those obtained from healthy control subjects using the selective DAT radioligand [99mTc]TRODAT-1 and single photon emission computed tomography imaging. We hypothesized that DAT levels might be higher in bipolar versus unipolar patients. Methods: [99mTc]TRODAT-1 scans were acquired from 5 bipolar and 10 unipolar patients and from 46 healthy controls. Distribution volume ratio (DVR) of [99mTc]TRODAT-1 binding affinity was calculated for regions of interest in the striatum. Results: Bipolar patients had greater DVR values compared to controls in the right posterior putamen (p = 0.001) and in the left caudate region (p = 0.007). Bipolar patients had modestly lower DAT binding in all brain regions examined, and a significantly lower DVR in the right caudate region compared to unipolar patients (p = 0.05). Conclusion: These data suggest that striatal DAT density may be increased in bipolar and unipolar depressed patients compared to controls, and that bipolar and unipolar depressed patients may have a different pattern of striatal DAT binding.


  

Author Contacts

Jay D. Amsterdam, MD
Depression Research Unit, University Science Center, 3rd floor
3535 Market Street
Philadelphia, PA 19104 (USA)
Tel. +1 215 662 3462, Fax +1 215 662 6443, E-Mail jamsterd@mail.med.upenn.edu

  

Article Information

Received: November 22, 2006
Accepted after revision: May 27, 2007
Published online: July 26, 2007
Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 1, Number of References : 23

  

Publication Details

Neuropsychobiology (International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography)

Vol. 55, No. 3-4, Year 2007 (Cover Date: October 2007)

Journal Editor: Strik, W. (Bern)
ISSN: 0302–282X (print), 1423–0224 (Online)

For additional information: http://www.karger.com/NPS


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/22/2006
Accepted: 5/27/2007
Published online: 7/26/2007

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


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