Prevalence of Dementia amongst Elderly Japanese with Leprosy: Apparent Effect of Chronic Drug TherapyMcGeer P.L. · Harada N. · Kimura H. · McGeer E.G. · Schulzer M.
a Kinsmen Laboratory of Neurological Research, University of B.C., Vancouver, Canada; b National Leprosarium Oku Komyo-en, Okayama-ken, Japan; c Institute of Molecular Neurobiology, Shiga University of Medical Sciences, Japan; d Departments of Medicine and Statistics, University of B.C., Vancouver, Canada
The overall prevalence of dementia in 1,410 Japanese leprosy patients 65 years or over continuously treated with dapsone or closely related drugs was 2.9%. This compares with 4.83% of 621 cases treated intermittently and 6.25 % of 1,761 cases untreated for at least 5 years. Multiple logistic regression analysis showed a highly significant increase of dementia with age (p = 0.0001) and, after age adjustment, a significant reduction of dementia in drug-treated compared with drug-free patients (p = 0.017). Such treatment had no significant effect on the prevalence of strokes. These data suggest that dapsone and closely related drugs may have potential use as antidementia agents.
Dr. Patrick L. McGeer, Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, Vancouver, B.C. V6T 1W5 (Canada)
Accepted: January 13, 1992
Number of Print Pages : 4
Dementia and Geriatric Cognitive Disorders
Vol. 3, No. 3, Year 1992 (Cover Date: 1992)
Journal Editor: Chan-Palay, V. (New York, N.Y.)
ISSN: 1420–8008 (print), 1421–9824 (Online)
For additional information: http://www.karger.com/DEM