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Vol. 3, No. 3, 1992
Issue release date: 1992
Section title: Original Research Article
Dement Geriatr Cogn Disord 1992;3:146–149
(DOI:10.1159/000107010)

Prevalence of Dementia amongst Elderly Japanese with Leprosy: Apparent Effect of Chronic Drug Therapy

McGeer P.L. · Harada N. · Kimura H. · McGeer E.G. · Schulzer M.
a Kinsmen Laboratory of Neurological Research, University of B.C., Vancouver, Canada; b National Leprosarium Oku Komyo-en, Okayama-ken, Japan; c Institute of Molecular Neurobiology, Shiga University of Medical Sciences, Japan; d Departments of Medicine and Statistics, University of B.C., Vancouver, Canada

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: 6/5/1992
Issue release date: 1992

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

The overall prevalence of dementia in 1,410 Japanese leprosy patients 65 years or over continuously treated with dapsone or closely related drugs was 2.9%. This compares with 4.83% of 621 cases treated intermittently and 6.25 % of 1,761 cases untreated for at least 5 years. Multiple logistic regression analysis showed a highly significant increase of dementia with age (p = 0.0001) and, after age adjustment, a significant reduction of dementia in drug-treated compared with drug-free patients (p = 0.017). Such treatment had no significant effect on the prevalence of strokes. These data suggest that dapsone and closely related drugs may have potential use as antidementia agents.


  

Author Contacts

Dr. Patrick L. McGeer, Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, Vancouver, B.C. V6T 1W5 (Canada)

  

Article Information

Accepted: January 13, 1992
Number of Print Pages : 4

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 3, No. 3, Year 1992 (Cover Date: 1992)

Journal Editor: Chan-Palay, V. (New York, N.Y.)
ISSN: 1420–8008 (print), 1421–9824 (Online)

For additional information: http://www.karger.com/DEM


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: 6/5/1992
Issue release date: 1992

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.