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Cover

Nutrigenomics - Opportunities in Asia

1st ILSI International Conference on Nutrigenomics, Singapore, December 2005

Editor(s): Tai E.S. (Singapore) 
Gillies P.J. (Newark, Del.) 
Table of Contents
Vol. 60, No. , 2007
Section title: Paper
Tai ES, Gillies PJ (eds): Nutrigenomics - Opportunities in Asia. Forum Nutr. Basel, Karger, 2007, vol 60, pp 140-145
(DOI:10.1159/000107090)

Genetic Polymorphisms in Folate- Metabolizing Enzymes and Risk of Gastroesophageal Cancers: A Potential Nutrient-Gene Interaction in Cancer Development

Lin D.a · Li H.b · Tan W.a · Miao X.a · Wang L.b
aDepartment of Etiology and Carcinogenesis, Cancer Institute/Hospital and bDepartment of Epidemiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: August 07, 2007
Cover Date: 2007

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8216-2 (Print)
eISBN: 978-3-318-01499-0 (Online)

Abstract

Folate deficiency has been associated with certain types of human cancer. We therefore investigated the effects of genetic polymorphisms in folate-metabolizing enzymes on the risk of developing gastroesophageal cancers in a Chinese population where folate deficiency is common. We found that functional polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS), two key enzymes involved in folate and methyl group metabolism, were significantly associated with increased risk of esophageal squamous cell carcinoma, gastric cardia carcinoma, and pancreatic carcinoma. The polymorphisms modulate risk of these cancers associated with low folate status. Our results suggest that MTHFR and TS genotypes may be determinant of gastroesophageal cancers in this at-risk Chinese population.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: August 07, 2007
Cover Date: 2007

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8216-2 (Print)
eISBN: 978-3-318-01499-0 (Online)


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.