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Vol. 14, No. 1, 2007
Issue release date: August 2007
Section title: Original Paper
Neuroimmunomodulation 2007;14:24–31
(DOI:10.1159/000107285)

Use of Electroacupuncture at ST36 to Inhibit Anaphylactic and Inflammatory Reaction in Mice

Moon P.-D. · Jeong H.-J. · Kim S.-J. · An H.-J. · Lee H.-J. · Yang W.M. · Park S.K. · Hong S.-H. · Kim H.-M. · Um J.-Y.
aDepartment of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, bAcupuncture and Meridian Science Research Center, cDepartment of Prescriptionology, College of Oriental Medicine, Kyung Hee University, Seoul, and dCollege of Pharmacy, Wonkwang University, Jeonbuk, Republic of Korea

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/21/2006
Accepted: 2/17/2007
Published online: 8/15/2007

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 3

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM

Abstract

Objective: Electroacupuncture (EA) has been used to treat myalgia, allergy and gastroenteropathy in Korea. To determine whether EA can treat anaphylactic and inflammatory reactions, the effect of EA was investigated in a murine model. Methods: EA stimulation of the ST36 acupoint was performed for 10 min. Using a passive cutaneous anaphylaxis (PCA) model, the antianaphylactic effects of EA were examined. Interleukin-6 and tumor necrosis factor-α were measured using the ELISA method. The level of nuclear factor (NF)-ĸB/RelA protein and NF-ĸB DNA-binding activity was determined using the Western blot analysis and the transcription factor enzyme-linked immunoassay method. Results: EA inhibits PCA and β-hexosaminidase release, IL-6 secretion on the PCA, and in addition, EA reduces NF-ĸB DNA-binding activity. Conclusion: These results indicate that EA may possess antianaphylactic and antiinflammatory properties.


  

Author Contacts

Jae-Young Um, PhD
College of Oriental Medicine, Institute of Oriental Medicine
Kyung Hee University, Dongdaemun-Gu
Seoul 130-701 (Republic of Korea)
Tel. +82 2 961 9262, Fax +82 2 967 7707, E-Mail jyum@khu.ac.kr

  

Article Information

Received: November 21, 2006
Accepted: February 17, 2007
Published online: August 15, 2007
Number of Print Pages : 8
Number of Figures : 3, Number of Tables : 3, Number of References : 50

  

Publication Details

Neuroimmunomodulation

Vol. 14, No. 1, Year 2007 (Cover Date: August 2007)

Journal Editor: Savino, W. (Rio de Janeiro)
ISSN: 1021–7401 (print), 1423–0216 (Online)

For additional information: http://www.karger.com/NIM


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/21/2006
Accepted: 2/17/2007
Published online: 8/15/2007

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 3

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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