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Acute Stroke Management: Brain Protection, Reperfusion and Improving Recovery after Stroke

Neuroprotection in Cerebral Infarction: The Opportunity of New Studies

Pérez de la Ossa N. · Dávalos A.

Author affiliations

Stroke Unit, Department of Neurosciences, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain

Related Articles for ""

Cerebrovasc Dis 2007;24:153–156

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Article / Publication Details

First-Page Preview
Abstract of Acute Stroke Management: Brain Protection, Reperfusion and Improving Recovery after Stroke

Published online: November 01, 2007
Issue release date: November 2007

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED

Abstract

Therapeutic options in the acute phase of a stroke are limited despite a great number of neuroprotectant drugs that have been developed in the last few decades. Although neuroprotection has been proved in animal models, translation of experimental efficacy into clinical benefit in humans is a difficult task. With the aim of bringing closer laboratory and clinical results, a change and unification of the methodology used is needed. Evaluating neuroprotectant capacity to salvage the penumbra using MRI both in animals and humans as a surrogate outcome can help to select drugs more likely to demonstrate clinical benefit. In addition, neuroprotection should enlarge the window of opportunity for reperfusion therapies and protect vascular structures to reduce reperfusion injury and the clinical complications related to thrombolytic treatment. A better understanding of ischemic and restorative brain mechanisms beyond the acute phase of stroke may open new therapeutic options to improve stroke recovery.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Acute Stroke Management: Brain Protection, Reperfusion and Improving Recovery after Stroke

Published online: November 01, 2007
Issue release date: November 2007

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


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