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Table of Contents
Vol. 24, Suppl. 1, 2007
Issue release date: November 2007
Section title: Acute Stroke Management: Brain Protection, Reperfusion and Improving Recovery after Stroke
Cerebrovasc Dis 2007;24:167–180
(DOI:10.1159/000107393)

Neuroplasticity and Cellular Therapy in Cerebral Infarction

Rodríguez-González R. · Hurtado O. · Sobrino T. · Castillo J.
Clinical Neuroscience Research Laboratory, Division of Vascular Neurology, Department of Neurology, Hospital Clínico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain

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Article / Publication Details

First-Page Preview
Abstract of Acute Stroke Management: Brain Protection, Reperfusion and Improving Recovery after Stroke

Published online: November 01, 2007
Issue release date: November 2007

Number of Print Pages: 14
Number of Figures: 4
Number of Tables: 0

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED

Abstract

Stroke is the second to third most common cause of death in adults, and more than a third of people who survive a stroke will have severe disability. Therapeutic options currently centre on fibrinolytic treatment, but its limitations restrict use to a small proportion of patients. Although a wide range of neuroprotective substances has been effective in experimental models, they have repeatedly failed in clinical trials because of toxicity or loss of effectiveness. Recent strategies based on neuroplasticity and cellular therapy have shown significant efficacy in improving functional recovery in experimental models, although further study is still necessary to clarify how the brain responds to ischaemic damage and is able to reorganize itself in the long term. Although steps must still be taken to ensure the safety and feasibility of treatments based on neuroplasticity and cellular therapy, neurorepair strategies provide promising future therapeutic options for stroke.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Acute Stroke Management: Brain Protection, Reperfusion and Improving Recovery after Stroke

Published online: November 01, 2007
Issue release date: November 2007

Number of Print Pages: 14
Number of Figures: 4
Number of Tables: 0

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.