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Vol. 51, No. 4, 2007
Issue release date: September 2007
Section title: Original Paper
Ann Nutr Metab 2007;51:379–386
(DOI:10.1159/000107687)

Taurine Induces Anti-Anxiety by Activating Strychnine-Sensitive Glycine Receptor in vivo

Zhang C.G. · Kim S.-J.
aDepartment of Pharmacology and Metabolic Diseases Research Laboratory, School of Dentistry, Kyung Hee University, bAge-Related and Brain Diseases Research Center, Kyung Hee University, Seoul, Korea, and cDepartment of Neuropsychiatry, Yan Bian University College of Clinical Medicine, Yan Gi, China

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/26/2006
Accepted: 3/9/2007
Published online: 8/29/2007

Number of Print Pages: 8
Number of Figures: 9
Number of Tables: 0

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM

Abstract

Taurine has a variety of actions in the body such as cardiotonic, host-defensive, radioprotective and glucose-regulatory effects. However, its action in the central nervous system remains to be characterized. In the present study, we tested to see whether taurine exerts anti-anxiety effects and to explore its mechanism of anti-anxiety activity in vivo. The staircase test and elevated plus maze test were performed to test the anti-anxiety action of taurine. Convulsions induced by strychnine, picrotoxin, yohimbine and isoniazid were tested to explore the mechanism of anti-anxiety activity of taurine. The Rotarod test was performed to test muscle relaxant activity and the passive avoidance test was carried out to test memory activity in response to taurine. Taurine (200 mg/kg, p.o.) significantly reduced rearing numbers in the staircase test while it increased the time spent in the open arms as well as the number of entries to the open arms in the elevated plus maze test, suggesting that it has a significant anti-anxiety activity. Taurine’s action could be due to its binding to and activating of strychnine-sensitive glycine receptor in vivo as it inhibited convulsion caused by strychnine; however, it has little effect on picrotoxin-induced convulsion, suggesting its anti-anxiety activity may not be linked to GABA receptor. It did not alter memory function and muscle activity. Taken together, these results suggest that taurine could be beneficial for the control of anxiety in the clinical situations.


  

Author Contacts

Sung-Jin Kim
Department of Pharmacology and Metabolic Diseases Research Laboratory
School of Dentistry, Kyung Hee University
Seoul 130-701 (Korea)
Tel. +82 961 0868, Fax +82 2 957 5309, E-Mail kimsj@khu.ac.kr

  

Article Information

Received: May 26, 2006
Accepted: March 9, 2007
Published online: August 29, 2007
Number of Print Pages : 8
Number of Figures : 9, Number of Tables : 0, Number of References : 33

  

Publication Details

Annals of Nutrition and Metabolism (Journal of Nutrition, Metabolic Diseases and Dietetics)

Vol. 51, No. 4, Year 2007 (Cover Date: September 2007)

Journal Editor: Elmadfa, I. (Vienna)
ISSN: 0250–6807 (print), 1421–9697 (Online)

For additional information: http://www.karger.com/ANM


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/26/2006
Accepted: 3/9/2007
Published online: 8/29/2007

Number of Print Pages: 8
Number of Figures: 9
Number of Tables: 0

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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