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Vol. 58, No. 4, 2007
Issue release date: November 2007
Section title: Original Paper
Eur Neurol 2007;58:218–223
(DOI:10.1159/000107943)

Motor and Nonmotor Symptom Follow-Up in Parkinsonian Patients after Deep Brain Stimulation of the Subthalamic Nucleus

Zibetti M. · Torre E. · Cinquepalmi A. · Rosso M. · Ducati A. · Bergamasco B. · Lanotte M. · Lopiano L.
aDepartment of Neuroscience, University of Turin, Turin, and bS. Maugeri Foundation, Pavia, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/29/2006
Accepted: 3/13/2007
Published online: 9/7/2007

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 1

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE

Abstract

Objective: To evaluate motor and nonmotor symptoms in patients with Parkinson’s disease undergoing bilateral deep brain stimulation of the subthalamic nucleus (STN DBS). Methods: Thirty-six consecutive patients receiving bilateral STN stimulation implants were evaluated preoperatively as well as 12 and 24 months after surgery. Motor symptoms were assessed through the Unified Parkinson’s Disease Rating Scale (UPDRS). Data concerning nonmotor symptoms were collected from items of the UPDRS and 2 additional questions from clinical charts regarding constipation and urological dysfunction. Results: STN DBS was effective in controlling motor symptoms; concerning nonmotor symptoms, sleep quality and constipation improved after surgery as compared to baseline. Salivation, swallowing and sensory complaints were ameliorated to a comparable degree by the medication on state, whether preoperatively or postoperatively. With a lower dose of dopaminergic medication, however, the medication on state appeared to be a much larger percentage of the day postoperatively. No significant variations were detected in intellectual impairment, depression, thought disorders, motivation, falling unrelated to freezing, nausea, orthostatic hypotension and urological dysfunction. Conclusions: STN DBS effectively controls motor symptoms, while nonmotor features of advanced Parkinson’s disease patients are mostly unchanged after surgery, even though some specific aspects, notably sleep complaints and constipation, are ameliorated.


  

Author Contacts

Dr. Maurizio Zibetti
Department of Neuroscience, University of Turin
Via Cherasco 15
IT–10126 Turin (Italy)
Tel. +39 011 633 5089, Fax +39 011 696 3487, E-Mail mzibetti@molinette.piemonte.it

  

Article Information

Received: November 29, 2006
Accepted: March 13, 2007
Published online: September 7, 2007
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 1, Number of References : 36

  

Publication Details

European Neurology

Vol. 58, No. 4, Year 2007 (Cover Date: November 2007)

Journal Editor: Bogousslavsky, J. (Montreux)
ISSN: 0014–3022 (print), 1421–9913 (Online)

For additional information: http://www.karger.com/ENE


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/29/2006
Accepted: 3/13/2007
Published online: 9/7/2007

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 1

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE


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